Never say die: survival signaling in large granular lymphocyte leukemia.
Never say die: survival signaling in large granular lymphocyte leukemia.
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DOI：
10.3816/clm.2009.s.019
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Loughran TP Jr
中科院分区：
文献类型：
--
作者：
Shah MV;Zhang R;Loughran TP Jr
大颗粒淋巴细胞白血病是一种罕见的成熟细胞毒性T细胞或NK细胞的疾病。LGL白血病的特征是细胞毒性细胞在血液中积聚并浸润骨髓、肝脏和脾脏。现就LGL白血病的临床特点作一综述。我们的讨论集中在已知的生存信号被认为在LGL白血病的发病机制中发挥作用及其潜在的治疗意义。
Large granular lymphocyte (LGL) leukemia is a rare disorder of either mature cytotoxic T- or NK- cells. LGL leukemia is characterized by accumulation of cytotoxic cells in blood and infiltration in bone marrow, liver and spleen. Here we review clinical features of LGL leukemia. We focus our discussion on known survival signals believed to play role in pathogenesis of LGL leukemia and their potential therapeutic implications.