HLA-DW3 ASSOCIATED WITH CŒLIAC DISEASE

HLA-DW3 ASSOCIATED WITH CŒLIAC DISEASE
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DOI：
10.1016/s0140-6736(76)90294-4
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发表时间：
1976-03
期刊：
The Lancet
影响因子：
--
通讯作者：
J. Keuning;A. Peña;J. Hooff;A. Leeuwen;J. J. Rood-J.
J. Keuning;A. Peña;J. Hooff;A. Leeuwen;J. J. Rood-J.
中科院分区：
其他
文献类型：
--
作者：
J. Keuning;A. Peña;J. Hooff;A. Leeuwen;J. J. Rood-J.

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28例乳糜泻（C.D.）患者通过几种技术对HLA-A、-B和-D位点进行分型。发现C.D.主要与DW 3决定簇相关，其次与HLA-B8相关。先前描述的与HLA-B8的关联由HLA-B8和DW 3之间的连锁不平衡来解释。
28 patients with cœliac disease (C.D.) were typed for the HLA-A, -B, and -D loci by several techniques. It was found that C.D. is primarily associated with the DW3 determinant and only secondarily with HLA-B8. The previously described association with HLA-B8 is explained by linkage disequilibrium between HLA-B8 and DW3.