Bone marrow stromal cells generate muscle cells and repair muscle degeneration
Bone marrow stromal cells generate muscle cells and repair muscle degeneration
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DOI：
10.1126/science.1110364
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发表时间：
2005-07-08
期刊：
影响因子：
56.9
通讯作者：
Nabeshima, Y
中科院分区：
文献类型：
--
作者：
Dezawa, M;Ishikawa, H;Nabeshima, Y
骨髓基质细胞（MSCs）作为治疗剂具有巨大的潜力。我们报道了一种从人和大鼠的贴壁间充质干细胞中诱导骨骼肌谱系细胞的方法，其效率为89%。诱导细胞移植到大鼠和mdx裸小鼠变性肌肉后分化为肌纤维。诱导的群体含有Pax7阳性细胞，其在重复损伤后有助于随后的肌肉再生，而无需额外的细胞移植。这些间充质干细胞比通常在肌肉和骨髓中发现的罕见肌源性干细胞更容易提供肌源性细胞。
Bone marrow stromal cells (MSCs) have great potential as therapeutic agents. We report a method for inducing skeletal muscle lineage cells from human and rat general adherent MSCs with an efficiency of 89%. Induced cells differentiated into muscle fibers upon transplantation into degenerated muscles of rats and mdx-nude mice. The induced population contained Pax7-positive cells that contributed to subsequent regeneration of muscle upon repetitive damage without additional transplantation of cells. These MSCs represent a more ready supply of myogenic cells than do the rare myogenic stem cells normally found in muscle and bone marrow.