Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-D-mannosyl phosphate transferase
Synthesis of potential bisubstrate inhibitors of Leishmania elongating α-D-mannosyl phosphate transferase
复制标题
DOI：
10.1016/j.tetlet.2003.11.022
复制
发表时间：
2004-01-19
影响因子：
1.8
通讯作者：
Nikolaevk, AV
中科院分区：
文献类型：
--
作者：
Borodkin, VS;Ferguson, MAJ;Nikolaevk, AV
成功地合成了利什曼原虫延伸的α-D-甘露糖基磷酸转移酶的潜在双底物抑制物1，包括通过亚甲基双膦酸链接合到合成受体底物上的鸟苷亚基及其类似物2和3。(C)2003爱思唯尔有限公司。保留所有权利。
Synthesis of a potential mechanism-based bisubstrate inhibitor 1 of the elongating alpha-D-mannosyl phosphate transferase in Leishmania, comprising a guanosine subunit bound to the synthetic acceptor substrate through the methylenebisphosphonate linker, as well as its analogues 2 and 3 has been successfully accomplished. (C) 2003 Elsevier Ltd. All rights reserved.