The virtual international stroke trials archive
The virtual international stroke trials archive
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DOI：
10.1161/strokeaha.106.473579
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发表时间：
2007-06-01
期刊：
影响因子：
8.3
通讯作者：
Lees, Kennedy R.
中科院分区：
文献类型：
--
作者：
Ali, Myzoon;Bath, Philip M. W.;Lees, Kennedy R.
背景和目的-脑卒中具有全球重要性，它导致越来越多的人类痛苦和经济负担，但其管理远非最佳。几个研究项目的失败结果突出了对可靠数据的需求，以规划未来的临床试验。虚拟国际中风试验档案旨在帮助规划的临床试验，整理和提供访问丰富的资源，病人的数据进行explorative analysis.Methods -数据的主要研究者的许多试验，从过去的16年。这些数据已被集中整理，并可用于匿名分析和假设testing.Results -目前，虚拟国际中风试验档案包含21个试验。有超过15000例缺血性和出血性卒中患者的数据。年龄在18岁至103岁之间，平均年龄为69 +/- 12岁。结果测量包括Barthel指数、斯堪的纳维亚卒中量表、国立卫生研究院卒中量表、Orgogozo量表和改良兰金量表。病史和发病-治疗时间是现成的，计算机断层扫描病变数据可用于选定的trials.Conclusions -这种资源有可能影响临床试验的设计和实施，通过数据分析，告知规划。
Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of several research programs highlights the need for reliable data on which to plan future clinical trials. The Virtual International Stroke Trials Archive aims to aid the planning of clinical trials by collating and providing access to a rich resource of patient data to perform exploratory analyses.Methods - Data were contributed by the principal investigators of numerous trials from the past 16 years. These data have been centrally collated and are available for anonymized analysis and hypothesis testing.Results - Currently, the Virtual International Stroke Trials Archive contains 21 trials. There are data on > 15 000 patients with both ischemic and hemorrhagic stroke. Ages range between 18 and 103 years, with a mean age of 69 +/- 12 years. Outcome measures include the Barthel Index, Scandinavian Stroke Scale, National Institutes of Health Stroke Scale, Orgogozo Scale, and modified Rankin Scale. Medical history and onset- to- treatment time are readily available, and computed tomography lesion data are available for selected trials.Conclusions - This resource has the potential to influence clinical trial design and implementation through data analyses that inform planning.