An Independent Positive Relationship Between the Serum Total Osteocalcin Level and Fat-Free Mass in Healthy Premenopausal Women
An Independent Positive Relationship Between the Serum Total Osteocalcin Level and Fat-Free Mass in Healthy Premenopausal Women
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健康绝经前女性血清总骨钙素水平与去脂体重之间存在独立正相关关系。
DOI：
10.1210/jc.2013-1112
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发表时间：
2013-05-01
影响因子：
5.8
通讯作者：
Ning, Guang
中科院分区：
文献类型：
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作者：
Liu, Jian-min G.;Zhao, Hong-yan;Ning, Guang
背景：据广泛报道，骨钙素与脂肪量呈负相关。然而，很少有报道描述其与去脂体重的相关性，特别是在女性中。 目的：本研究的目的是调查骨钙素与健康非肥胖女性的去脂体重之间可能存在的关系。 设计和背景：本研究在一所三级大学教学医院进行。受试者：总共招募了 504 名 20-75 岁的健康女性。 主要结果指标：使用生物电子阻抗分析仪测量身体成分。检测血清总骨钙素、雌二醇、瘦素、骨保护素、核因子κB配体受体激活剂、IGF-I、空腹血糖、尿I型胶原N端端肽浓度。采用双能X射线骨密度仪测量腰椎和近端股骨颈处的骨矿物质密度（BMD）。结果：调整年龄、脂肪量、绝经状态、雌二醇、空腹血糖、瘦素、骨保护素、核受体激活剂后，血清总骨钙素水平与去脂质量呈显着正相关（r = 0.168，P = .007）。 Kappa B 因子配体、IGF-I、I 型胶原蛋白 N 末端端肽、BMD 以及腰围和臀围。对绝经前和绝经后女性的分析表明，这种关联仅存在于绝经前女性中（r = 0.190，P = .005）。多元逐步回归分析显示，臀围、股骨颈BMD、脂肪量、瘦素、骨钙素和年龄是绝经前女性去脂体重变化的影响因素（调整后的R-2 = 0.521，P
Context: It is widely reported that osteocalcin is negatively associated with fat mass. However, there are few reports describing its correlation with fat-free mass, particularly in women.Objectives: The objective of the current study was to investigate the possible relationship between osteocalcin and fat-free mass in healthy, nonobese women.Design and Setting: This study was performed in a tertiary university teaching hospital. Subjects: A total of 504 healthy women aged 20-75 years were enrolled.Main outcome measures: Body composition was measured using a bioelectronics impedance analyzer. The serum concentrations of total osteocalcin, estradiol, leptin, osteoprotegerin, the receptor activator of nuclear factor-kappa B ligand, IGF-I, fasting plasma glucose, and urinary N-terminal telopeptide of type I collagen were tested. The bone mineral densities (BMDs) at the lumbar spine and proximal femoral neck were measured by dual-energy X-ray absorptiometry.Results: The serum total osteocalcin level had a significant positive association with fat-free mass (r = 0.168, P = .007) after adjusting for age, fat mass, menopausal status, estradiol, fasting glucose, leptin, osteoprotegerin, receptor activator of nuclear factor-kappa B ligand, IGF-I, N-terminal telopeptide of type I collagen, BMDs, and waist and hip circumference. Analysis in pre-and postmenopausal women demonstrated that this association was only present in premenopausal women (r = 0.190, P = .005). The multiple stepwise regression analysis revealed that hip circumference, femoral neck-BMD, fat mass, leptin, osteocalcin, and age are the contributors to the changes in fat-free mass in premenopausal women (adjusted R-2 = 0.521, P