Mouse models in skeletal physiology and osteoporosis: experiences and data on 14839 cases from the Hamburg Mouse Archives
Mouse models in skeletal physiology and osteoporosis: experiences and data on 14839 cases from the Hamburg Mouse Archives
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骨骼生理学和骨质疏松症的小鼠模型：汉堡小鼠档案馆 14839 例病例的经验和数据
DOI：
10.1007/bf03026332
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发表时间：
2009
影响因子：
3.3
通讯作者：
M. Amling
中科院分区：
文献类型：
--
作者：
P. Pogoda;M. Priemel;A. Schilling;M. Gebauer;Philip Catalá;F. Barvencik;F. Beil;C. Münch;M. Rupprecht;C. Müldner;J. Rueger;T. Schinke;M. Amling;P. Pogoda;M. Priemel;A. Schilling;M. Gebauer;P. Catalá;F. Barvencik;F. Beil;C. Munch;M. Rupprecht;C. Miildner;J. Rueger;T. Schinke;M. Amling
我们对骨骼发育生物学的理解，就像对生物学中几乎所有其他学科的理解一样，已经被人类和小鼠遗传学的最新进展所改变，但我们对骨骼生理学的分子和遗传学仍然知之甚少。因此，在许多问题中，很大程度上是无法解释的是：为什么骨质疏松症主要是妇女的疾病？在青春期结束和性腺功能停止之间，骨量是如何保持几乎恒定的？分子遗传学已经成为研究骨骼生理学以前未探索的方面的有力工具。在哺乳动物中，小鼠是这项实验工作最有希望的动物。转基因动物对我们研究领域的贡献取决于我们对小鼠骨骼表型特征的描述。事实上，一个给定的小鼠模型的骨骼特征的充分赞赏需要应用标准化的协议，非侵入性成像，组织学，组织形态学，生物力学，并单独适应在体外和体内分析。在过去的几年里，我们已经建立了一个小鼠档案，其中包括14839例来自120多个不同的小鼠模型，我们在汉堡的表型特征。今天，这是最大的老鼠骨骼数据库之一。这篇综述集中在骨骼生理学的一个方面，即骨骼衰老，并表明小鼠模型可以是一个有价值的工具，以获得在骨骼生理学的某些方面，以前尚未探索的见解。
Our understanding of the developmental biology of the skeleton, like that of virtually every other subject in biology, has been transformed by recent advances in human and mouse genetics, but we still know very little, in molecular and genetic terms, about skeletal physiology. Thus, among the many questions that are largely unexplained are the following: why is osteoporosis mainly a women’s disease? How is bone mass maintained nearly constant between the end of puberty and the arrest of gonadal functions? Molecular genetics has emerged as a powerful tool to study previously unexplored aspects of the physiology of the skeleton. Among mammals, mice are the most promising animals for this experimental work. The input that transgenic animals can offer to our field depends on our means of phenotypic characterization of the mouse skeleton. In fact, full appreciation of the skeletal characteristics of a given mouse model requires the application of standardized protocols for noninvasive imaging, histology, histomorphometry, biomechanics, and individually adapted in vitro and in vivo analysis. Over the past years we have established a mouse archive that consists of 14839 cases from more than 120 different mouse models that we have phenotypically characterized in Hamburg. Today, this is one of the biggest databases on the mouse skeleton. This review focuses on one aspect of skeletal physiology, namely skeletal aging, and demonstrates that mouse models can be a valuable tool to gain insights in certain facets of skeletal physiology that have been unexplored previously.
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影响因子：
4.1
作者：
Beamer, WG;Donahue, LR;Baylink, DJ
通讯作者：
Baylink, DJ
DOI：
10.1016/0169-6009(92)90809-r
发表时间：
1992-09-01
期刊：
BONE AND MINERAL
影响因子：
--
作者：
FROST, HM;JEE, WSS
通讯作者：
JEE, WSS
单纯疱疹病毒胸苷激酶/更昔洛韦介导的旁观者细胞凋亡。
DOI：
--
发表时间：
1996
期刊：
Cancer research.
影响因子：
--
作者：
Hamel,W;Magnelli,L;Chiarugi,VP;Israel,MA
通讯作者：
Israel,MA
影响因子：
15.9
作者：
Lanske, B;Amling, M;Kronenberg, HM
通讯作者：
Kronenberg, HM
影响因子：
15.9
作者：
Jilka, RL;Weinstein, RS;Manolagas, SC
通讯作者：
Manolagas, SC