Body composition and pulmonary function in the elderly: a 7-year longitudinal study
Body composition and pulmonary function in the elderly: a 7-year longitudinal study
复制标题
DOI：
10.1038/ijo.2008.103
复制
发表时间：
2008-09-01
影响因子：
4.9
通讯作者：
Zamboni, M.
中科院分区：
文献类型：
--
作者：
Rossi, A.;Fantin, F.;Zamboni, M.
目的：在7年的随访期内，评估老年男性和女性样本中身体成分、脂肪分布和肺功能变化之间的关系。设计：纵向临床研究。共有47名女性和30名男性，年龄分别为71.6 ± 2.3岁和71.7 ± 2.2岁，在基线时，体重指数（BMI）值为24.96 +/- 3.28和27.04 +/- 3.35 kg/m（-2），随访7年。体重、腰围、矢状腹径（SAD），通过双能X线吸收测定法（DXA）和1秒用力呼气量（FEV 1）和用力肺活量（FVC）测量的去脂质量（FFM）和脂肪质量结果：在女性和男性中，体重、SAD和BMI没有显著变化。在女性和男性中观察到身高和FFM显著降低。在7年的随访中，女性和男性的身高调整FEV 1和FVC显著降低。在分别考虑基线FEV 1和FVC后，SAD的变化是FEV 1和FVC 7年随访的最有力预测因子。以7年随访肺功能变量为因变量，身体成分变量变化为自变量进行线性回归分析，结果显示SAD增加1 cm预测FEV 1和FVC分别减少31和46 ml，FFM减少1 kg预测FVC减少38 ml。在将我们的研究人群细分为四类FFM和SAD的变化后，FFM降低和SAD增加的患者表现出FEV 1和FVC恶化的最高概率。结论：腹部脂肪增加和FFM下降是老年人肺功能下降的重要预测因子。出现腹部脂肪增加和FFM减少的老年受试者显示肺功能恶化的可能性最高。
Objective: To evaluate over a 7-year follow-up period the relationships between changes in body composition, fat distribution and pulmonary function in a sample of elderly men and women.Design: Longitudinal clinical study.Subjects: A total of 47 women and 30 men aged 71.6 +/- 2.3 and 71.7 +/- 2.2 years, respectively, at baseline with body mass index (BMI) values of 24.96 +/- 3.28 and 27.04 +/- 3.35 kg m(-2) were followed for 7 years.Measurements: Body weight, waist circumference, sagittal abdominal diameter (SAD), fat-free mass (FFM) and fat mass as measured by dual energy X-ray absorptiometry (DXA) and forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) by spirometry were evaluated at baseline and after a 7-year mean follow-up.Results: In women as in men there were no significant changes in weight, SAD and BMI. A significant decrease in height and FFM was observed in both women and men. Height-adjusted FEV1 and FVC decreased significantly in women and men over the 7-year follow-up. Changes in SAD were the most powerful predictors of 7-year follow-up of FEV1 and FVC after taking into account, respectively, baseline FEV1 and FVC. Linear regression analysis, performed by using 7-year follow-up lung function variables as dependent variables and changes in body composition variables as independent variables, showed that 1 cm SAD increase predicted a decrease in FEV1 and FVC of 31 and 46 ml, respectively, and 1 kg FFM decrease predicted a decrease in FVC of 38 ml. After subdividing our study population into four categories of change in FFM and SAD, patients with decreased FFM and increased SAD showed the highest probability of having a worsening in FEV1 and FVC.Conclusion: Increase in abdominal fat and FFM decline are significant predictors of lung function decline in the elderly. Old subjects developing both abdominal fat gain and FFM loss show the highest probability of developing worsening in lung function.