Simple regioisomeric differentiation of 2-, 3- and 4-methyl-α-pyrrolidinobutiophenones by gas chromatography-mass spectrometry using bromination
Simple regioisomeric differentiation of 2-, 3- and 4-methyl-α-pyrrolidinobutiophenones by gas chromatography-mass spectrometry using bromination
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通过溴化气相色谱-质谱法简单区分 2-、3- 和 4-甲基-α-吡咯烷丁苯酮
DOI：
10.1007/s11419-016-0329-6
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发表时间：
2017
影响因子：
2.2
通讯作者：
Shin-ichi Kubo
中科院分区：
文献类型：
--
作者：
Hiroshi Fujii;Brian Waters;Kenji Hara;Masayuki Kashiwagi;Aya Matsusue;Shin-ichi Kubo
建立了一种用溴代法区分卡西酮型2-、3-和4-甲基-α-吡咯烷基丁二酮（MePBPs）的方法。溴化在小瓶中进行，其中加入MePBP的异构体、溴化铁（III）和液溴。在将小瓶中过量的溴抽空并加入碱性溶液后，用正己烷萃取化合物并通过气相色谱-质谱法分析。这种方法是一种有用的方式来区分异构体之间的MePBP使用的峰的数量和提取的离子色谱图上的峰之间的强度比的差异。该方法在其他药物的区域异构体鉴别中具有很大的应用潜力。
A simple method for the differentiation of three cathinone-type regioisomers, 2-, 3- and 4-methyl-α-pyrrolidinobutiophenone (MePBPs), using a bromination procedure was developed in this study. The bromination was performed in a vial where isomers of MePBP, iron(III) bromide, and liquid bromine were added. After excess bromine in the vial was evacuated and an alkaline solution was added, the compounds were extracted withn-hexane and analyzed by gas chromatography–mass spectrometry. This method is a useful way to differentiate among isomers of MePBPs using the differences in the number of peaks generated and the intensity ratio between peaks on the extracted ion chromatograms. This method seems to have great potential to be applied to regioisomer differentiation of other drugs.