A five-year prospective study of fatigue in primary Sjögren's syndrome.
A five-year prospective study of fatigue in primary Sjögren's syndrome.
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DOI：
10.1186/ar3487
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发表时间：
2011
影响因子：
4.9
通讯作者：
Brun JG
中科院分区：
文献类型：
--
作者：
Haldorsen K;Bjelland I;Bolstad AI;Jonsson R;Brun JG
疲劳在原发性干燥综合征 (pSS) 中很常见，并导致该疾病中健康相关的生活质量大大降低。该症状包含在针对 pSS 的拟议疾病活动和结果测量中。多项研究表明，pSS 和其他慢性炎症性风湿性疾病中存在疲劳的炎症成分。本研究的目的是在纵向研究中调查 pSS 的疲劳变化，并探讨基线时的任何临床或实验室变量（包括血清细胞因子）是否与疲劳评分随时间的变化相关。 2004 年 5 月至 2005 年 4 月期间，对 141 名符合 pSS 欧美共识标准的患者进行了临床和实验室调查。诊断后的中位时间为 5.5 年。检查内容包括疲劳问卷：疲劳严重程度量表（FSS）、疲劳视觉模拟量表（VAS）、慢性病治疗功能评估-疲劳（FACIT-F）和医疗结果研究简式36（SF-36）活力，这些在2010年1月和2月的随访调查中重复进行。在两个时间点共有122名患者（87%）做出了回应。百分之三十五的患者经历了临床上显着的 FSS 增加。在团体层面上，除了 SF-36 活力得分略有恶化外，疲劳指标没有变化。高血清抗干燥综合征 A 抗原（抗 SSA）与高基线疲劳关联较弱，疲劳程度增加的患者基线未刺激总唾液量较低。观察到疲劳加剧与血清免疫球蛋白 G (IgG) 和促炎细胞因子白细胞介素 17 (IL-17) 之间的微弱关联。基线干燥症状与基线时较高的疲劳程度以及随着时间的推移而增加的疲劳程度相关。线性回归分析没有发现临床或实验室测量对疲劳随时间变化的任何预测能力。随着时间的推移，疲劳程度基本保持不变。使用多变量模型没有揭示疲劳随时间变化的任何临床或实验室预测因素。
Fatigue is prevalent in primary Sjögren's syndrome (pSS), and contributes to the considerably reduced health related quality of life in this disease. The symptom is included in proposed disease activity and outcome measures for pSS. Several studies indicate that there is an inflammatory component of fatigue in pSS and other chronic inflammatory rheumatic diseases. The purpose of this study was to investigate fatigue change in pSS in a longitudinal study, and explore whether any clinical or laboratory variables at baseline, including serum cytokines, were associated with a change in fatigue scores over time. A clinical and laboratory investigation of 141 patients fulfilling the American-European consensus criteria of pSS was undertaken in the period May 2004 to April 2005. Median time since diagnosis was 5.5 years. Examinations included the fatigue questionnaires: fatigue severity scale (FSS), fatigue visual analogue scale (VAS), functional assessment of chronic illness therapy - fatigue (FACIT-F) and medical outcome study short form-36 (SF-36) vitality, which were repeated in a follow-up investigation in January and February 2010. A total of 122 patients (87%) responded at both time-points. Thirty-five percent of patients experienced a clinically significant FSS increase. On the group level, fatigue measures did not change except that there was a slight deterioration in SF-36 vitality score. High serum anti-Sjögren's syndrome A antigen (anti-SSA) showed weak associations with high baseline fatigue, and patients with increasing fatigue had lower baseline unstimulated whole salivary volume. Weak associations between increasing fatigue and serum immunoglobulin G (IgG), and the pro-inflammatory cytokine interleukin-17 (IL-17), were observed. Baseline sicca symptoms correlated with higher fatigue both at baseline and with increasing fatigue over time. Linear regression analysis did not identify any predictive ability of clinical or laboratory measures on fatigue change over time. Fatigue remained mainly unchanged over time. Using multivariate models did not reveal any clinical or laboratory predictors of fatigue change over time.
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影响因子：
2.1
作者：
Baturone, R.;Soto, M. J.;Giron-Gonzalez, J. A.
通讯作者：
Giron-Gonzalez, J. A.
影响因子：
27.4
作者：
Haldorsen, K.;Moen, K.;Brun, J. G.
通讯作者：
Brun, J. G.
影响因子：
5.5
作者：
Reksten, Tove R.;Jonsson, Malin V.;Brokstad, Karl A.
通讯作者：
Brokstad, Karl A.
影响因子：
27.4
作者：
Hartkamp, A;Geenen, R;Derksen, RHWM
通讯作者：
Derksen, RHWM
影响因子：
5.5
作者：
Theander, Lisa;Strombeck, Britta;Theander, Elke
通讯作者：
Theander, Elke