THE NEUROTOXICITY OF AFLATOXIN-B1 IN THE RAT
THE NEUROTOXICITY OF AFLATOXIN-B1 IN THE RAT
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DOI：
10.1016/0300-483x(83)90121-x
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发表时间：
1983-01-01
期刊：
影响因子：
4.5
通讯作者：
IKEGWUONU, FI
中科院分区：
文献类型：
--
作者：
IKEGWUONU, FI
重复I.P.的影响。观察黄曲霉毒素B1对大鼠外周神经系统和中枢神经系统的影响。在黄曲霉毒素B1给药后和停药后监测神经组织中神经毒性的生化指标。黄曲霉毒素B1提高了两个系统中β-葡萄糖醛酸酶和β-半乳糖苷酶的活性。黄曲霉毒素B1可激活Na+，K+-ATPase，抑制Mg2+-ATPase。黄曲霉毒素B1可使神经组织DNA和总蛋白含量升高，而RNA和磷脂含量降低。在恢复过程中，这些参数的变化是针对每个组织的。反复给大鼠服用黄曲霉毒素B1导致系统退化，这可能与黄曲霉毒素注射后观察到的明显毒性有关。
The effects of repeated i.p. administration of aflatoxin B1 on the peripheral nervous system and CNS of rats were investigated. Biochemical markers of neurotoxicty were monitored in nervous tisues following aflatoxin B1 dosage and after the cessation of alfatoxin B1 administration. Aflatoxin B1 increased the activities of .beta.-glucuronidase and .beta.-galactosidase in both systems. Repeated exposure of rats to aflatoxin B1 also activated Na+, K+-ATPase and inhibited Mg2+-ATPase. Nervous tissue levels of DNA and total protein increased while the concentrations of RNA and phospholipid were depressed by aflatoxin B1. The alterations in these parameters were specific for each tissue during recovery. Repeated administration of aflatoxin B1 to rats resulted in degeneration in systems that may have been related to the overt toxicity observed following aflatoxin administration.