The effect of growth hormone replacement therapy on cortisol–cortisone interconversion in hypopituitary adults: evidence for growth hormone modulation of extrarenal 11β‐hydroxysteroid dehydrogenase activity
The effect of growth hormone replacement therapy on cortisol–cortisone interconversion in hypopituitary adults: evidence for growth hormone modulation of extrarenal 11β‐hydroxysteroid dehydrogenase activity
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生长激素替代疗法对垂体功能低下成人皮质醇-可的松相互转化的影响：生长激素调节肾外 11β-羟基类固醇脱氢酶活性的证据
DOI：
10.1046/j.1365-2265.1998.00364.x
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发表时间：
1998
影响因子：
3.2
通讯作者：
J. Monson
中科院分区：
文献类型：
--
作者：
S. Gelding;N. Taylor;P. Wood;K. Noonan;J. Weaver;D. Wood;J. Monson
生长激素(GH)替代治疗与11-羟基/11-氧-皮质醇代谢物(COM)尿比例降低有关。这可能是由于生长激素调节肝脏或肾脏的11β-羟基类固醇脱氢酶(11β-HSD1和2)的活性，这些酶负责皮质醇-皮质醇的相互转化，或者也可能反映皮质醇可获得性的降低。为了阐明这一点，我们研究了随着氢化可的松替代剂量的增加，生长激素对甲状腺功能低下的成年人尿皮质醇、皮质醇和皮质醇代谢产物的影响。
Growth hormone (GH) replacement therapy in hypopituitary adults has been associated with a decreased urinary ratio of 11‐hydroxy/11‐oxo‐cortisol metabolites (CoM). This could result from GH regulation of the activity of hepatic or renal 11β‐hydroxysteroid dehydrogenase (11β‐HSD1 and 2), the enzymes responsible for cortisol–cortisone interconversion, or alternatively it might reflect decreased cortisol availability. To elucidate this, we examined the effect of GH on urinary cortisol, cortisone and cortisol metabolites in hypopituitary adults at increasing doses of hydrocortisone replacement.
影响因子：
5.8
作者：
HAMMAMI, MM;SIITERI, PK
通讯作者：
SIITERI, PK