Telomere shortening as a hallmark of stem cell senescence.
Telomere shortening as a hallmark of stem cell senescence.
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DOI：
10.21037/sci.2019.02.04
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发表时间：
2019-01-01
影响因子：
--
通讯作者：
Farahzadi, Raheleh
中科院分区：
文献类型：
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作者：
Fathi, Ezzatollah;Charoudeh, Hojjatollah Nozad;Farahzadi, Raheleh
干细胞，尤其是间充质干细胞(MSCs)通过多向分化、自我更新等特性在再生医学中得到了极大的关注。尽管MSCs具有上述优点，但这些细胞的特定特性受到年龄的强烈影响。因此，来自老年捐赠者的MSCs的使用率低于年轻捐赠者，这限制了细胞治疗的临床应用。根据衰老理论，认为衰老很可能是由端粒缩短引起的，端粒缩短被认为是衰老的标志。找出这些变化的大多数机制可能会揭示延长人类健康和改善与年龄相关的表型的新的治疗靶点。本文就干细胞端粒缩短衰老机制及其分子机制的研究进展作一综述。
Stem cells, especially mesenchymal stem cells (MSCs)-based therapies have been greatly attentioned in regenerative medicine through multi-lineage differentiation, self-renewal properties, etc. Despite the above advantages of MSCs, the defined properties of these cells are strongly affected by aging. Thus, the use of MSCs from older donors is lower than younger one, which limits clinical applications in cell therapy. According to the theories of aging, it is determined that aging is most likely caused by telomere shortening and telomere shortening is considered hallmarks of aging. Finding out the most mechanisms of these changes will probably reveal novel therapeutic targets for prolonging human health and for ameliorating age-associated phenotypes. This review focuses on prevalent knowledge about the mechanisms of stem cell senescence by telomere shortening and the molecular mechanism details involved in it.