PREDOMINANCE OF TYPE-1 COLLAGEN AT SURFACE OF AVIAN ARTICULAR-CARTILAGE
PREDOMINANCE OF TYPE-1 COLLAGEN AT SURFACE OF AVIAN ARTICULAR-CARTILAGE
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DOI：
10.1016/0014-5793(78)80468-2
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发表时间：
1978-01-01
期刊：
影响因子：
3.5
通讯作者：
GLIMCHER, MJ
中科院分区：
文献类型：
--
作者：
EYRE, DR;BRICKLEYPARSONS, DM;GLIMCHER, MJ
哺乳动物透明软骨中的胶原蛋白，包括主要关节的关节软骨，似乎都是II型分子[1 -3]。相反，纤维软骨，如膝关节半月板的纤维软骨，主要含有I型胶原[3]，椎间盘是一种特殊的纤维软骨，含有I型和II型胶原，它们以高度特异性的方式以相反的浓度梯度分布[4,5]。鸡的关节软骨与哺乳动物的关节软骨不同，除了含有II型胶原蛋白外，还含有大量的I型胶原蛋白[6,7]。由于有研究表明，人关节软骨中从II型胶原合成到I型胶原合成的转换可能是骨关节病发病的一个关键因素[f& 10]，因此评估I型胶原在正常关节软骨中的分布和作用是很重要的。在本研究中，已经评估了鸡膝关节软骨中I型和II型胶原比例随年龄和关节面深度的变化。I型总含量在孵化后增加。成熟时成为胶原蛋白的主要成分。在所有年龄段，I型胶原基本上是关节表面唯一的胶原类型，随着深度的增加，它逐渐与II型胶原交换。六糖胺含量和蛋白聚糖含量随深度的增加而增加，与II型含量的增加明显一致。软骨
The collagen in hyaline cartilages of mammals, including articular cartilage of the major joints, appears to be all of molecular type II [l-3]. In contrast, fibrocartilage, such as that of the knee meniscus, contains mainly type I collagen [3], and intervertebral disc, a specialized fibrocartilage, contains types I and II distributed in opposing concentration gradients in a highly specific manner [4, 5]. Articular cartilage of the chicken was shown to differ from that of the mammal by containing a significant proportion of type I collagen in addition to type II [6, 7]. Since it has been suggested that a switch in synthesis from type II to type I collagen in human articular cartilage may be a crucial factor in the pathogenesis of osteoarthrosis [f&-10], the distribution and role of type I in normal avain articular cartilage are important to evaluate.In the present study, changes with age and with depth from the articular surface in the proportions of types I and II collagens in chicken knee cartilage have been assessed. The total content of type I increased after hatching. becoming the major collagen component at maturity. At all ages type I was essentially the only collagen type at the articular surface and it gradually interchanged with type II with increasing depth. The content of hexosamines, and hence of proteoglycans, increased with depth apparently in unison with the rising type II content. Cartilages