Relationships between Cerebral Vasculopathies and Microinfarcts in a Community-Based Cohort of Older Adults.
Relationships between Cerebral Vasculopathies and Microinfarcts in a Community-Based Cohort of Older Adults.
复制标题
DOI：
10.3390/jcm12113807
复制
发表时间：
2023-06-01
影响因子：
3.9
通讯作者：
Ahmed, Ali
中科院分区：
文献类型：
--
作者：
Sin, Mo-Kyung;Cheng, Yan;Roseman, Jeffrey M.;Zamrini, Edward;Ahmed, Ali
脑微梗死与认知障碍和痴呆有关。小血管疾病如脑小动脉硬化和脑淀粉样血管造影（CAA）已被发现与微梗死有关。这些血管病变与微梗死的存在、数量和位置之间的关系尚不清楚。这些关联在成人思维变化（ACT）研究的842名参与者的临床和尸检数据中进行了检验。两种血管病变按严重程度（无、轻度、中度和重度）和区域（皮质和皮质下）分类。估计与小动脉硬化和CAA相关的微梗死的优势比（OR）和95% CIs，校正了可能的协变量，如死亡年龄、性别、血压、APOE基因型、Braak和CERAD。417例（49.5%）有微梗死（皮质301例，皮质下249例），708例（84.1%）有脑小动脉硬化，320例（38%）有CAA， 284例（34%）两者兼有。中度（n = 183）和重度（n = 124）小动脉硬化患者微梗死的or （95% CI）分别为2.16（1.46-3.18）和4.63（2.90-7.40）。微梗死数的or （95% CI）分别为2.25（1.54-3.30）和4.91（3.18-7.60）。在皮层和皮层下微梗死中也观察到类似的关联。与轻度（n = 75）、中度（n = 73）和重度（n = 15）淀粉样血管病相关的微梗死数的or （95% Cis）分别为0.95（0.66-1.35）、1.04（0.71-1.52）和2.05（0.94-4.45）。皮质微梗死的or （95% Cis）分别为1.05（0.71-1.56）、1.50（0.99-2.27）和1.69（0.73-3.91）。皮质下微梗死的or （95% Cis）分别为0.84（0.55-1.28）、0.72（0.46-1.14）和0.92（0.37-2.28）。这些研究结果表明，脑小动脉硬化与微梗死的存在、数量和位置（皮质和皮质下）存在显著关联，而CAA与每个微梗死存在微弱且不显著的关联，强调了未来研究的必要性，以更好地了解小血管疾病在脑微梗死发病机制中的作用。
Cerebral microinfarcts are associated with cognitive impairment and dementia. Small vessel diseases such as cerebral arteriolosclerosis and cerebral amyloid angiography (CAA) have been found to be associated with microinfarcts. Less is known about the associations of these vasculopathies with the presence, numbers, and location of microinfarcts. These associations were examined in the clinical and autopsy data of 842 participants in the Adult Changes in Thought (ACT) study. Both vasculopathies were categorized by severity (none, mild, moderate, and severe) and region (cortical and subcortical). Odds ratios (OR) and 95% CIs for microinfarcts associated with arteriolosclerosis and CAA adjusted for possible modifying covariates such as age at death, sex, blood pressure, APOE genotype, Braak, and CERAD were estimated. 417 (49.5%) had microinfarcts (cortical, 301; subcortical, 249), 708 (84.1%) had cerebral arteriolosclerosis, 320 (38%) had CAA, and 284 (34%) had both. Ors (95% CI) for any microinfarct were 2.16 (1.46–3.18) and 4.63 (2.90–7.40) for those with moderate (n = 183) and severe (n = 124) arteriolosclerosis, respectively. Respective Ors (95% CI) for the number of microinfarcts were 2.25 (1.54–3.30) and 4.91 (3.18–7.60). Similar associations were observed for cortical and subcortical microinfarcts. Ors (95% Cis) for the number of microinfarcts associated with mild (n = 75), moderate (n = 73), and severe (n = 15) amyloid angiopathy were 0.95 (0.66–1.35), 1.04 (0.71–1.52), and 2.05 (0.94–4.45), respectively. Respective Ors (95% Cis) for cortical microinfarcts were 1.05 (0.71–1.56), 1.50 (0.99–2.27), and 1.69 (0.73–3.91). Respective Ors (95% Cis) for subcortical microinfarcts were 0.84 (0.55–1.28), 0.72 (0.46–1.14), and 0.92 (0.37–2.28). These findings suggest a significant association of cerebral arteriolosclerosis with the presence, number, and location (cortical and subcortical) of microinfarcts, and a weak and non-significant association of CAA with each microinfarct, highlighting the need for future research to better understand the role of small vessel diseases in the pathogenesis of cerebral microinfarcts.
登录
查看更多内容
DOI：
10.1016/j.ajpath.2021.07.004
发表时间：
2021-11
期刊：
The American journal of pathology
影响因子：
--
作者：
Kalaria RN;Sepulveda-Falla D
通讯作者：
Sepulveda-Falla D
影响因子：
4
作者：
Cholerton, Brenna;Larson, Eric B.;Montine, Thomas J.
通讯作者：
Montine, Thomas J.
影响因子：
39.2
作者：
Larson, EB;Wang, L;Kukull, W
通讯作者：
Kukull, W
影响因子：
11.2
作者：
Sonnen, Joshua A.;Larson, Eric B.;Montine, Thomas J.
通讯作者：
Montine, Thomas J.
DOI：
10.1016/s1474-4422(11)70307-6
发表时间：
2012-03
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Smith EE;Schneider JA;Wardlaw JM;Greenberg SM
通讯作者：
Greenberg SM