The Subthalamic Nucleus Contributes to Post-error Slowing
The Subthalamic Nucleus Contributes to Post-error Slowing
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DOI：
10.1162/jocn_a_00659
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发表时间：
2014-11-01
影响因子：
3.2
通讯作者：
Frank, Michael J.
中科院分区：
文献类型：
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作者：
Cavanagh, James F.;Sanguinetti, Joseph L.;Frank, Michael J.
pFC被提出来通过对行为的直接自上而下的影响来实现认知控制。但这一壮举是如何实现的呢？这种描述性模型的优点取决于对运动执行在特定情况下如何改变的机械理解。在这份报告中，我们提供的证据表明，著名的现象，减慢RT以下的错误（错误后减慢）是直接影响的程度，丘脑底核（ESTA）的活动。在冲突或错误发生后，建议将运动控制器作为运动执行的制动器，争取时间，以便在下一次试验中做出更谨慎的反应。记录了9名接受脑深部电刺激手术的帕金森病患者在执行反应冲突任务时的局部场电位。在以前与冲突和错误处理相关的2.5至5 Hz频率范围内，响应之前的相位一致性程度与越来越慢的RT相关，特别是在错误之后。这些发现提供了令人信服的证据，错误后减慢部分是由皮质丘脑底核超直接通路介导的，以增加反应谨慎。
pFC is proposed to implement cognitive control via directed top-down influence over behavior. But how is this feat achieved? The virtue of such a descriptive model is contingent on a mechanistic understanding of how motor execution is altered in specific circumstances. In this report, we provide evidence that the well-known phenomenon of slowed RTs following mistakes (post-error slowing) is directly influenced by the degree of subthalamic nucleus (STN) activity. The STN is proposed to act as a brake on motor execution following conflict or errors, buying time so a more cautious response can be made on the next trial. STN local field potentials from nine Parkinson disease patients undergoing deep brain stimulation surgery were recorded while they performed a response conflict task. In a 2.5- to 5-Hz frequency range previously associated with conflict and error processing, the degree phase consistency preceding the response was associated with increasingly slower RTs specifically following errors. These findings provide compelling evidence that post-error slowing is in part mediated by a corticosubthalamic hyperdirect pathway for increased response caution.