The reelin pathway modulates the structure and function of retinal synaptic circuitry
The reelin pathway modulates the structure and function of retinal synaptic circuitry
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DOI：
10.1016/s0896-6273(01)00436-6
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发表时间：
2001-09-27
期刊：
影响因子：
16.2
通讯作者：
Curran, T
中科院分区：
文献类型：
--
作者：
Rice, DS;Nusinowitz, S;Curran, T
突触连接的形成需要特定的引导分子和自发神经元活动的协调。视觉系统提供了一个有用的模型来理解这些线索在塑造从神经视网膜到大脑的精确连接中的作用。在这里，我们证明了两个必不可少的基因在Reelin信号通路的功能在视网膜的突触连接的图案。对缺乏reelin或disabled-1的小鼠的生理学研究揭示了杆驱动视网膜反应的衰减。这种缺陷与视杆双极细胞密度降低和内网状层突起分布异常有关。这些结果意味着，除了其在神经元迁移过程中的重要作用外，Reelin通路还有助于中枢神经系统中神经元回路的形成。
The formation of synaptic connections requires the coordination of specific guidance molecules and spontaneous neuronal activity. The visual system has provided a useful model for understanding the role of these cues in shaping the precise connections from the neural retina to the brain. Here, we demonstrate that two essential genes in the Reelin signaling pathway function during the patterning of synaptic connectivity in the retina. Physiological studies of mice deficient in either reelin or disabled-1 reveal an attenuation of rod-driven retinal responses. This defect is associated with a decrease in rod bipolar cell density and an abnormal distribution of processes in the inner plexiform layer. These results imply that, in addition to its essential role during neuronal migration, the Reelin pathway contributes to the formation of neuronal circuits in the central nervous system.