Rhodium-Catalyzed Directed C-H Cyanation of Arenes with N-Cyano-N-phenyl-p-toluenesulfonamide
Rhodium-Catalyzed Directed C-H Cyanation of Arenes with N-Cyano-N-phenyl-p-toluenesulfonamide
复制标题
铑催化 N-氰基-N-苯基-对甲苯磺酰胺对芳烃的直接 C-H 氰化
DOI：
10.1021/ja405742y
复制
发表时间：
2013-07-24
影响因子：
15
通讯作者：
Fu, Yao
中科院分区：
文献类型：
--
作者：
Gong, Tian-Jun;Xiao, Bin;Fu, Yao
首次发展了铑催化的C-H直接氰化反应，作为合成芳腈的一种实用方法。在转化中使用了一种方便的氰化试剂N-氰基-N-苯基-对甲苯磺酰胺。许多不同的导向基团可用于该C-H氰化过程中，并且该反应容许各种合成上重要的官能团。
A Rh-catalyzed directed C-H cyanation reaction was developed for the first time as a practical method for the synthesis of aromatic nitriles. N-Cyano-N-phenyl-p-toluenesulfonamide, a user-friendly cyanation reagent, was used in the transformation. Many different directing groups can be used in this C-H cyanation process, and the reaction tolerates a variety of synthetically important functional groups.