Circadian clock and cancer: From a viewpoint of cellular differentiation
Circadian clock and cancer: From a viewpoint of cellular differentiation
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DOI：
10.1111/iju.14231
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发表时间：
2020-03
影响因子：
2.6
通讯作者：
Yoshiki Tsuchiya;Yasuhiro Umemura;K. Yagita
中科院分区：
文献类型：
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作者：
Yoshiki Tsuchiya;Yasuhiro Umemura;K. Yagita
生物钟根据地球24小时的环境变化周期控制和适应各种生理和行为过程。哺乳动物生物钟的主起搏器位于下丘脑视交叉上核，但几乎所有的细胞在整个身体的基因表达模式和相关功能的昼夜节律振荡。最近的研究表明，生物钟在胚胎发育过程中逐渐发展。胚胎干细胞和诱导多能干细胞不显示基因表达的昼夜节律振荡，但在分化过程中逐渐产生昼夜节律钟振荡;因此，昼夜节律钟出现的发育程序似乎与细胞分化密切相关。像胚胎干细胞一样，某些癌细胞类型也缺乏生物钟。鉴于胚胎干细胞和癌细胞之间的这种相似性，人们越来越关注生物钟功能障碍对去分化和癌症发展的贡献。在这篇综述中，我们总结了最近的进展，在我们的理解，生物钟出现在个体发育，并讨论可能与细胞分化和癌变。考虑到昼夜节律的多种生理功能，昼夜节律异常可能导致许多疾病，包括癌症。对昼夜节律功能的了解可能会导致识别癌症诊断和预后的生物标志物，以及新的治疗靶点。
The circadian clock controls and adapts diverse physiological and behavioral processes according to Earth’s 24‐h cycle of environmental changes. The master pacemaker of the mammalian circadian clock resides in the hypothalamic suprachiasmatic nucleus, but almost all cells throughout the body show circadian oscillations in gene expression patterns and associated functions. Recent studies have shown that the circadian clock gradually develops during embryogenesis. Embryonic stem cells and induced pluripotent stem cells do not show circadian oscillations of gene expression, but gradually develop circadian clock oscillation during differentiation; thus, the developmental program of circadian clock emergence appears closely associated with cellular differentiation. Like embryonic stem cells, certain cancer cell types also lack the circadian clock. Given this similarity between embryonic stem cells and cancer cells, interest is growing in the contributions of circadian clock dysfunction to dedifferentiation and cancer development. In this review, we summarize recent advances in our understanding of circadian clock emergence during ontogenesis, and discuss possible associations with cellular differentiation and carcinogenesis. Considering the multiple physiological functions of circadian rhythms, circadian abnormalities might contribute to a host of diseases, including cancer. Insights on circadian function could lead to the identification of biomarkers for cancer diagnosis and prognosis, as well as novel targets for treatment.