The impact of young age on the prognosis for colorectal cancer: a population-based study in Taiwan
The impact of young age on the prognosis for colorectal cancer: a population-based study in Taiwan
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DOI：
10.1093/jjco/hyx110
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发表时间：
2017-11-01
影响因子：
2.4
通讯作者：
Shiue, Yow-Ling
中科院分区：
文献类型：
--
作者：
Chou, Chia-Lin;Tseng, Chien-Jen;Shiue, Yow-Ling
年龄作为结直肠癌（CRC）患者预后因素的影响仍然存在争议，可能是由于研究之间在患者数量、接受根治性切除术的患者百分比、接受新辅助治疗的患者百分比或未能调整潜在混杂因素方面的异质性。本研究使用台湾癌症登记数据库中的结直肠癌生存数据，以综合分析年龄作为预后因素，分析1998年至2005年间62 060例诊断为腺癌、粘液腺癌或印戒细胞癌的结直肠癌患者的生存数据。使用Kaplan-Meier分析确定全因死亡率和CRC相关死亡率，并使用对数秩检验比较不同年龄组之间的生存差异。根据单变量和多变量考克斯比例风险模型的估计值计算全因和CRC相关死亡率的粗风险比和校正风险比。
The impact of age as a prognostic factor for patients with colorectal cancer (CRC) remains controversial, possibly due to heterogeneity between studies in terms of patient numbers, percentage of patients undergoing curative resection, percentage of patients receiving neoadjuvant therapy, or failure to adjust for potential confounding factors. This study used colorectal cancer survival data from the Taiwan Cancer Registry database in order to comprehensively analyze age as a prognostic factor.Survival data were analyzed for 62 060 CRC patients diagnosed with adenocarcinoma, mucinous adenocarcinoma, or signet-ring cell carcinoma of the colon and rectum between 1998 and 2005. The rates of all-cause mortality and CRC-related mortality were determined using Kaplan-Meier analysis, and the log-rank test was used to compare differences in survival between different age groups. The crude and adjusted hazard ratios for all-cause and CRC-related mortalities were calculated according to the estimates from the univariable and multivariable Cox proportional hazard models.Patients in the