Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation
Induction of immediate-early genes c-fos and zif268 in the subnucleus oralis by noxious tooth pulp stimulation
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DOI：
10.1016/s0006-8993(98)00333-3
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发表时间：
1998-06
期刊：
影响因子：
2.9
通讯作者：
T. Sugimoto;Yi-Fen He;M. Funahashi;H. Ichikawa
中科院分区：
文献类型：
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作者：
T. Sugimoto;Yi-Fen He;M. Funahashi;H. Ichikawa
通过免疫细胞化学方法检测大鼠下颌切牙牙髓伤害性机械刺激后三叉神经感觉核复合体中c-Fos和Zif 268蛋白的表达。在刺激同侧的口亚核中观察到两个立即早期基因的显著上调。牙本质的腔制备没有达到纸浆没有引起显着的上调检测免疫细胞化学。这些结果提供了证据表明，有害的牙齿信号到达同侧口亚核和上调转录的立即早期基因c-fos和zif 268。
c-fos and zif268 expression were assessed by immunocytochemistry for c-Fos and Zif268 proteins in the sensory trigeminal nuclear complex following noxious mechanical stimulation of the mandibular incisor pulp of rats. Marked up-regulation of both immediate early genes was observed in the subnucleus oralis ipsilateral to the stimulation. Cavity preparation of the dentine without reaching the pulp did not cause significant up-regulation detectable by immunocytochemistry. These results provide evidence that noxious dental signals reach the ipsilateral subnucleus oralis and up-regulate the transcription of immediate early genes c-fos and zif268.