Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children
Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children
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DOI：
10.1016/s0168-1605(98)00056-7
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发表时间：
1998-06-30
影响因子：
5.4
通讯作者：
Mitsuoka, T
中科院分区：
文献类型：
--
作者：
Fukushima, Y;Kawata, Y;Mitsuoka, T
益生菌的抗感染作用最近已有报道，其机制之一可能是非特异性免疫刺激。本研究旨在阐明益生菌配方对健康儿童肠道菌群和局部免疫力的影响。研究人员给7名健康的日本儿童（15至31个月大）提供了含有活双歧杆菌的后续配方奶粉，持续21天。在摄入配方奶粉期间，在5名受试者（71%）的粪便中检测到了所施用的菌株，并且粪便中的细菌总数略有增加。粪便中总伊加和抗脊髓灰质炎病毒伊加水平在摄入配方奶粉期间显著高于摄入前（P
The anti-infectious effect of probiotics has recently been reported and one mechanism may be the non-specific stimulation of immunity. This study was performed to elucidate the influence of a probiotic formula on intestinal microflora and local immunity in healthy children. A follow-up formula containing viable bifidobacteria was given to seven healthy Japanese children (15 to 31 months old) for 21 days. During intake of the formula, the administered strain was detected in feces from five subjects (71%) and total fecal bifidobacteria slightly increased. Fecal levels of total IgA and anti-poliovirus IgA during intake of the formula were significantly higher than those before intake (P