Effect of a low-fat, high-carbohydrate dietary intervention on change in mammographic density over menopause
Effect of a low-fat, high-carbohydrate dietary intervention on change in mammographic density over menopause
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DOI：
10.1007/s10549-008-9904-9
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发表时间：
2009-01-01
影响因子：
3.8
通讯作者：
Boyd, Norman F.
中科院分区：
文献类型：
--
作者：
Martin, Lisa J.;Greenberg, Carolyn V.;Boyd, Norman F.
我们之前已经证明，与对照组相比，在乳腺摄影密度广泛的女性中进行2年的低脂饮食干预，可以更大程度地降低乳腺摄影密度。事后分析表明，这种影响是最强的妇女谁成为绝经后在随访期间。本研究的目的是确定这一潜在重要的发现是否可以在新的、更大的受试者群体中以更长的随访时间得到证实。对一项低脂饮食干预试验的参与者进行了检查，这些参与者在入组时处于绝经前，在随访期间处于绝经后。使用计算机辅助方法，在基线和绝经后乳房X线照片中测量乳腺总面积、致密区和非致密区以及密度百分比。与干预组相比，对照组的乳腺总面积和非致密区面积增加更多（乳腺面积分别为2.6和0.2 cm（2）; P = 0.05，非致密区分别为10.9和8.1 cm（2）; P = 0.06）。两组的致密区减少程度相似（分别为-8.2和-8.0 cm（2）; P = 0.84）。与干预组相比，对照组的百分比密度下降程度略大（分别为-9.4%和-7.8%，P = 0.11）。调整体重变化后，研究组之间没有显着差异。在低脂饮食组和对照组中，更年期降低密度的程度相似。如果低脂饮食可以降低乳腺癌的风险，那么这种效果不太可能是通过绝经期乳房X线摄影密度的变化来实现的。
We have previously shown that a low-fat dietary intervention for 2 years in women with extensive mammographic density decreased mammographic density to a greater extent than in the control group. Post-hoc analysis indicated that this effect was strongest in women who became postmenopausal during the follow-up period. The purpose of the present study was to determine if this potentially important finding could be confirmed in a new and larger group of subjects with a longer follow-up time. Participants in a low-fat dietary intervention trial who were premenopausal at entry and became postmenopausal during follow-up were examined. Total breast, dense, and non-dense area and percent density were measured in baseline and postmenopause mammograms using a computer-assisted method. Total breast and non dense area increased more in the control group compared to the intervention group (for breast area 2.6 and 0.2 cm(2), respectively; P = 0.05, and for non-dense area 10.9 and 8.1 cm(2), respectively; P = 0.06). Dense area decreased to a similar degree in both groups (-8.2 and -8.0 cm(2), respectively; P = 0.84). Percent density decreased to a slightly greater degree in the control compared to intervention group (-9.4 and -7.8%, respectively, P = 0.11). There were no significant differences between study groups after adjustment for weight change. Menopause reduced density to a similar extent in the low-fat diet and control groups. If a low-fat diet reduces breast cancer risk, the effect is unlikely to be through changes in mammographic density at menopause.