Emerging investigator series: the role of phage lifestyle in wastewater microbial community structures and functions: insights into diverse microbial environments
Emerging investigator series: the role of phage lifestyle in wastewater microbial community structures and functions: insights into diverse microbial environments
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DOI：
10.1039/d2ew00755j
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发表时间：
2023-06-02
影响因子：
5
通讯作者：
Al-Faliti，Mitham
中科院分区：
文献类型：
--
作者：
Vela，Jeseth Delgado;Al-Faliti，Mitham
一个多世纪以来，环境工程师一直试图控制原核生物群落的废水处理过程，但人们对了解和利用废水生物过程中噬菌体的活性越来越感兴趣。虽然噬菌体的存在和丰富已为人所知，但它们的生态作用、潜在的好处以及对废水生物过程的影响还不完全清楚。关于噬菌体如何感染宿主细胞的基础知识来自相对简单的纯培养研究，以及来自海洋和土壤系统的环境研究，可以用来预测噬菌体在不同和动态的废水环境中的潜在影响。这一前沿综述集中在关于噬菌体感染细菌的分子机制的已知情况，以及如何将其应用于废水处理系统中的生物过程控制和操作。在这里，我们特别关注推动噬菌体细胞内裂解和溶源的分子机制的研究要点，以及在生物废水过程中对抗生素耐药性基因传播和养分去除的影响。
For over a century, environmental engineers have attempted to control the prokaryotic community biological wastewater treatment processes, but there is growing interest in both understanding and harnessing the activity of phages in wastewater bioprocesses. While phages are known to be present and abundant, their ecological role, potential benefits, and impacts on wastewater biological processes are not fully understood. Fundamental knowledge on how phages infect host cells from relatively simple pure culture studies alongside environmental studies from marine and soil systems can be used to predict the potential impact of phages in diverse and dynamic wastewater environments. This frontier review is focused on what is known about the molecular mechanisms by which phages infect bacteria and how that could apply to biological process control and operation within wastewater treatment systems. Here, we specifically focus on highlights from studies on the molecular mechanisms that drive lysis and lysogeny within phage cells and the impacts on the dissemination of antibiotic resistance genes and nutrient removal within a biological wastewater process.