INCREASED MATERNAL-FETAL TRANSPORT OF FAT IN DIABETES ASSESSED BY POLY-UNSATURATED FATTY-ACID CONTENT IN FETAL LIPIDS
INCREASED MATERNAL-FETAL TRANSPORT OF FAT IN DIABETES ASSESSED BY POLY-UNSATURATED FATTY-ACID CONTENT IN FETAL LIPIDS
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DOI：
10.1159/000242138
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
SHAFRIR, E
中科院分区：
文献类型：
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作者：
GOLDSTEIN, R;LEVY, E;SHAFRIR, E
采用GLC法测定妊娠第20天链脲霉素糖尿病大鼠及其胎体几种组织提取物的总脂和甘油三酯组分中脂肪酸的分布。在母鼠中，除了脂肪组织和肝脏中亚油酸的相对含量有微小变化外，糖尿病对脂肪酸分布没有显著影响。在胎盘、胎体和胎肝中，甘油三酯含量增加了约1%。2倍是由于母体糖尿病，与母体循环中甘油三酯和游离脂肪酸的升高有关。胎盘（35%和59%）、胎体（56%和66%）和胎肝（100%和205%）的总脂质和甘油三酯提取物中亚油酸的相对含量显著增加。在一些胎儿组织中也可见到花生四烯酸比例的小幅增加。胎儿肝脏亚油酸的大量增加表明，该组织是过量转运到胎儿的母体脂质的重要摄取目标。该结果证实了先前关于糖尿病胎盘脂肪通道增加的观察结果，证明必需脂肪酸亚油酸的增加与糖尿病诱导的胎儿胎盘单位甘油三酯积累相似。
The distribution of fatty acids was determined by GLC in total lipid and triglyceride fraction of extracts of several tissues of streptozotocin-diabetic rats and their fetuses on day 20 of pregnancy. In maternal rats, diabetes did not significantly affect fatty acid distribution apart from small changes in the relative content of linoleate in adipose tissue and liver. In the placenta, the fetal carcass and the fetal liver the triglyceride content increased .apprx. 2-fold as a result of maternal diabetes, in association with the elevation in triglycerides and free fatty acids in the maternal circulation. A pronounced increase in the relative content of linoleate was recorded in the total lipid and triglyceride extracts of placenta (35 and 59%), fetal carcass (56 and 66%) and fetal liver (100 and 205%). Small increases in arachidonate proportion were also seen in some fetal tissues. The large increase in fetal hepatic linoleate indicates that this tissue is an important uptake target of maternal lipids transported in excess into the fetus. The results confirm the previous observations on increased transplacental fat passage in diabetes by demonstrating that the increment in the essential fatty acid, linoleate, parallels the diabetes-induced triglyceride accumulation in the fetoplacental unit.