Biochemical Genetic Pathways that Modulate Aging in Multiple Species.
Biochemical Genetic Pathways that Modulate Aging in Multiple Species.
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DOI：
10.1101/cshperspect.a025114
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发表时间：
2015-11-02
影响因子：
5.4
通讯作者：
Kaeberlein M
中科院分区：
文献类型：
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作者：
Bitto A;Wang AM;Bennett CF;Kaeberlein M
在过去的20年里，生物衰老的机制得到了广泛的研究，主要有四种模式生物：芽殖酵母酿酒酵母，线虫线虫线虫，果蝇和家鼠。对这四种模式生物的广泛研究已经确定了一些影响寿命以及新陈代谢和发育的保守遗传途径。在这里，我们回顾了雷帕霉素（mTOR），sirtuins，腺苷一磷酸活化蛋白激酶（AMPK），生长激素/胰岛素样生长因子1（IGF-1）和线粒体应激信号通路的机制目标如何影响上述模型中的衰老和寿命及其对延缓人类衰老的可能影响。我们还绘制了这些生化途径之间的一些联系，并评论了衰老研究在不久的将来可能带来的新发展。
The mechanisms underlying biological aging have been extensively studied in the past 20 years with the avail of mainly four model organisms: the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans, the fruitfly Drosophila melanogaster, and the domestic mouse Mus musculus. Extensive research in these four model organisms has identified a few conserved genetic pathways that affect longevity as well as metabolism and development. Here, we review how the mechanistic target of rapamycin (mTOR), sirtuins, adenosine monophosphate-activated protein kinase (AMPK), growth hormone/insulin-like growth factor 1 (IGF-1), and mitochondrial stress-signaling pathways influence aging and life span in the aforementioned models and their possible implications for delaying aging in humans. We also draw some connections between these biochemical pathways and comment on what new developments aging research will likely bring in the near future.