The association between HLA class I alleles and measles vaccine-induced antibody response: evidence of a significant association
The association between HLA class I alleles and measles vaccine-induced antibody response: evidence of a significant association
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DOI：
10.1016/s0264-410x(98)00017-6
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发表时间：
1998-11-01
期刊：
影响因子：
5.5
通讯作者：
Jacobsen, SJ
中科院分区：
文献类型：
--
作者：
Poland, GA;Jacobson, RM;Jacobsen, SJ
虽然Moraten株麻疹疫苗是一种优良、安全和免疫原性的疫苗，但疫苗失败可能发生在个体产生不充分的免疫应答时。在这项研究中，我们研究了HLA I类基因和麻疹疫苗诱导的抗体水平的关联。我们发现HLA-B等位基因的等位基因分布在无应答者和超应答者之间不同（p = 0.002）。Sever nl I类等位基因与无应答相关（HLA-B13、-B44和-C5）;而几个其他等位基因与超应答相关（HLA-B7和-B51）。此外，无应答者比正常应答者更可能是HLA-B纯合子（比值比2.1），比超应答者更可能是纯合子（比值比3.7，趋势p = 0.031 Mantel-Haenzel）。最后，我们发现了HLA-B7等位基因剂量反应现象的证据。我们的结论是，有重要的协会之间的I类HLA基因和麻疹抗体水平免疫接种。（C）1998 Elsevier Science Ltd.保留所有权利。
While the Moraten strain measles vaccine is an excellent, safe, and immunogenic vaccine, vaccine failure occurs, presumably when an individual develops an inadequate immune response. In this study, we examined the association of HLA class I genes and measles vaccine-induced antibody levels. We found that the allele distribution of HLA-B alleles differed between non-responders and hyper-responders (p = 0.002). Sever nl class I alleles were associated with non-response (HLA-B13, -B44, and -C5); whereas several other alleles were associated with hyper-response (HLA-B7 and -B51). In addition, non-responders were more likely to be HLA-B homozygous than normal responders (odds ratio 2.1), and more likely to be homozygous than hyper-responders (odds ratio 3.7, p = 0.031 Mantel-Haenzel for trend). Finally,, we found evidence of an allele dose-response phenomenon for HLA-B7. We conclude that there are important associations between class I HLA genes and measles antibody levels following immunization. (C)1998 Elsevier Science Ltd. All rights reserved.