HYPOTHERMIA PREVENTS ISCHEMIA-INDUCED INCREASES IN HIPPOCAMPAL GLYCINE CONCENTRATIONS IN RABBITS
HYPOTHERMIA PREVENTS ISCHEMIA-INDUCED INCREASES IN HIPPOCAMPAL GLYCINE CONCENTRATIONS IN RABBITS
复制标题
DOI：
10.1161/01.str.22.5.666
复制
发表时间：
1991-05-01
期刊：
影响因子：
8.3
通讯作者：
LARSON, AA
中科院分区：
文献类型：
--
作者：
BAKER, AJ;ZORNOW, MH;LARSON, AA
我们让10只新西兰大白兔在常温（37摄氏度）或中低温（29摄氏度）条件下进行10分钟的全脑缺血。使用体内微透析监测海马中谷氨酸、天冬氨酸和甘氨酸的浓度。结果通过神经学和神经病理学标准进行评估。低温对缺血性损伤提供了几乎完全的保护。在常温组（3倍、12倍和3倍基线）中，由缺血引起的谷氨酸、天冬氨酸和甘氨酸浓度升高在低温组中显著减弱。此外，在低温组中没有出现在恒温组中出现的持续的甘氨酸水平升高。这些结果表明，低温的神经保护特性可能部分地存在于它们能够防止细胞外氨基酸浓度的增加，从而增强n -甲基- d -天冬氨酸受体复合物的活性。
We subjected 10 New Zealand White rabbits to 10 minutes of global cerebral ischemia under either normothermic (37-degrees-C) or moderately hypothermic (29-degrees-C) conditions. Hippocampal concentrations of glutamate, aspartate, and glycine were monitored using in vivo microdialysis. Outcome was assessed by both neurological and neuropathologic criteria. Hypothermia afforded nearly complete protection from ischemic injury. Ischemia-induced increases in the concentrations of glutamate, aspartate, and glycine in the normothermic group (3, 12, and 3 times baseline) were strikingly attenuated in the hypothermic group. In addition, the prolonged postischemic elevation of glycine levels seen in the normothermic group was absent in the hypothermic group. These results suggest that the neuroprotective properties of hypothermia may reside, in part, in their ability to prevent increases in the extracellular concentrations of amino acids that enhance the activity of the N-methyl-D-aspartate receptor complex.