Chronic barbiturate treatment increases NMDA receptors but decreases kainate receptors in mouse cortex.
Chronic barbiturate treatment increases NMDA receptors but decreases kainate receptors in mouse cortex.
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长期巴比妥治疗会增加小鼠皮质中的 NMDA 受体，但会减少红藻氨酸受体。
DOI：
10.1016/0014-2999(93)90419-i
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发表时间：
1993
影响因子：
5
通讯作者：
Tabakoff,B
中科院分区：
文献类型：
--
作者：
Short,KR;Tabakoff,B
使用 [3H]MK-801 和 [3H]红藻氨酸评估苯巴比妥对脑 NMDA 和红藻氨酸受体的慢性影响。与对照小鼠相比，连续 7 天喂食苯巴比妥饮食的小鼠皮质中 MK-801 结合位点（NMDA 受体）密度较高，但红藻氨酸受体密度较低。在海马中未观察到 MK-801 或红藻氨酸结合的变化。结果表明，某些谷氨酸受体对长期巴比妥治疗有特定的大脑区域适应性。
Chronic phenobarbital effects on brain NMDA and kainate receptors were assessed using [3H]MK-801 and [3H]kainate. Mice fed a phenobarbital diet for 7 days had a higher density of MK-801 binding sites (NMDA receptors) but a lower density of kainate receptors in cortex than control mice. No changes in MK-801 or kainate binding were observed in hippocampus. The results suggest brain area specific adaptation of certain glutamate receptors to chronic barbiturate treatment.