OLFACTORY-EVOKED POTENTIALS - ASSESSMENT OF YOUNG AND ELDERLY, AND COMPARISON TO PSYCHOPHYSICAL THRESHOLD
OLFACTORY-EVOKED POTENTIALS - ASSESSMENT OF YOUNG AND ELDERLY, AND COMPARISON TO PSYCHOPHYSICAL THRESHOLD
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DOI：
10.1093/chemse/19.1.47
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发表时间：
1994-02-01
期刊：
影响因子：
3.5
通讯作者：
POLICH, J
中科院分区：
文献类型：
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作者：
MURPHY, C;NORDIN, S;POLICH, J
嗅觉诱发电位(OEPS)在青壮年和老年受试者的Fz、Cz和Pz电极上被单次记录，醋酸戊酯刺激呈嗅觉测量。乙酸戊酯的心理物理气味阈值是使用两种选择的强制选择检测程序确定的。这表明，与年轻受试者相比，老年人的气味检测敏感度降低。根据阈值结果，与年轻受试者相比，老年受试者产生的N1和P2幅度明显较小，并且潜伏期有延长的趋势。此外，还发现气味阈值与幅度大小有关。OEP的发现在之前的OEP研究的背景下进行了讨论，为临床和非临床环境中的感觉功能提供了一种客观的、非侵入性的测量方法。
Olfactory-evoked potentials (OEPs) were recorded monopolarly at the Fz, Cz and Pz electrode sites in young adults and elderly subjects with an amyl acetate stimulus presented olfactometrically. Psychophysical odor thresholds for amyl acetate were determined using a two-alternative, forced-choice detection procedure. These demonstrated a decreased odor detection sensitivity in the elderly relative to the young subjects. In accordance with the threshold findings, elderly subjects produced significantly smaller N1 and P2 amplitudes, and a trend towards longer latencies than younger subjects. Moreover, odor threshold was found to correlate with amplitude magnitude. The OEP findings, which are discussed in the context of previous OEP studies, offer promise as an objective, non-invasive measure of sensory function in both clinical and non-clinical settings.