Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease
Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease
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DOI：
10.1002/ana.24388
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发表时间：
2015-06-01
影响因子：
11.2
通讯作者：
Schneider, Julie A.
中科院分区：
文献类型：
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作者：
Nag, Sukriti;Yu, Lei;Schneider, Julie A.
目的探讨海马硬化（HS）与TAR-DNA结合蛋白43 kDa（TDP-43）及其他常见年龄相关疾病、痴呆、可能阿尔茨海默病（AD）、轻度认知功能障碍（MCI）和认知功能的关系。和MCI的636例尸检受试者来自宗教秩序研究和拉什记忆和衰老项目是基于临床评估和认知性能测试。HS定义为海马CA 1和/或下托中严重的神经元丢失和神经胶质增生。TDP-43的严重程度和分布进行了评估，和其他年龄相关的病理学也documented.ResultsHS是更常见的年龄>90岁（18.0%）相比，年轻的受试者（9.2%）。HS多伴有TDP-43病理改变（86%），以TDP-43病理改变更为严重（p
ObjectiveTo investigate the association of hippocampal sclerosis (HS) with TAR-DNA binding protein of 43kDa (TDP-43) and other common age-related pathologies, dementia, probable Alzheimer disease (AD), mild cognitive impairment (MCI), and cognitive domains in community-dwelling older subjects.MethodsDiagnoses of dementia, probable AD, and MCI in 636 autopsied subjects from the Religious Order Study and the Rush Memory and Aging Project were based on clinical evaluation and cognitive performance tests. HS was defined as severe neuronal loss and gliosis in the hippocampal CA1 and/or subiculum. The severity and distribution of TDP-43 were assessed, and other age-related pathologies were also documented.ResultsHS was more common in those aged >90 years (18.0%) compared to younger subjects (9.2%). HS cases commonly coexisted with TDP-43 pathology (86%), which was more severe (p