In search of principles for a Theory of Organisms.

In search of principles for a Theory of Organisms.
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DOI:
10.1007/s12038-015-9574-9
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发表时间:
2015-12
影响因子:
2.9
通讯作者:
Soto AM
Soto AM
中科院分区:
生物学4区
文献类型:
--
作者:
Longo G;Montevil M;Sonnenschein C;Soto AM

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缺乏一个操作理论来解释单细胞和多细胞生物中物质的组织和行为,阻碍了生物学的进步。这样的理论应该涉及从个体发育到死亡的生命周期。这一理论将补充进化论,解决生物起源,并将理论扩展到公认的物理原理和默认状态,以掌握物质的生活状态,并定义适当的生物学观察。因此,我们赞成采用默认状态隐含在达尔文的理论,即细胞增殖与变化加运动,和一个框架的原则,即生命现象表现为不相同的迭代形态发生过程。从这个角度来看,生物体成为增殖、运动和自组织产生的固有变异性的结果。形态发生是默认状态加上物理约束的结果,比如重力,以及生物体中存在的约束,比如肌肉张力。
Lacking an operational theory to explain the organization and behaviour of matter in unicellular and multicellular organisms hinders progress in biology. Such a theory should address life cycles from ontogenesis to death. This theory would complement the theory of evolution that addresses phylogenesis, and would posit theoretical extensions to accepted physical principles and default states in order to grasp the living state of matter and define proper biological observables. Thus, we favour adopting the default state implicit in Darwin’s theory, namely, cell proliferation with variation plus motility, and a framing principle, namely, life phenomena manifest themselves as non-identical iterations of morphogenetic processes. From this perspective, organisms become a consequence of the inherent variability generated by proliferation, motility and self-organization. Morphogenesis would then be the result of the default state plus physical constraints, like gravity, and those present in living organisms, like muscular tension.
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发表时间: 2012-08
影响因子: 3.8
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