Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI
Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI
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DOI：
10.1016/j.neuroimage.2015.02.010
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发表时间：
2015-05-01
期刊：
影响因子：
5.7
通讯作者：
Ourselin, Sebastien
中科院分区：
文献类型：
--
作者：
Eaton-Rosen, Zach;Melbourne, Andrew;Ourselin, Sebastien
早产是一个主要的公共卫生问题，随着早产的发生，不良后果的严重程度和发生率也会增加。早产会扰乱大脑的快速发育：除了体积增长之外，皮质会折叠，髓鞘形成，细胞水平也会发生变化。这些神经系统事件已使用扩散加权 (DW) MRI 进行非侵入性成像。在这一人群中，人们一直关注检查白质的扩散，但灰质对于神经健康也至关重要。我们获得了 12 名出生于
Preterm birth is a major public health concern, with the severity and occurrence of adverse outcome increasing with earlier delivery. Being born preterm disrupts a time of rapid brain development: in addition to volumetric growth, the cortex folds, myelination is occurring and there are changes on the cellular level. These neurological events have been imaged non-invasively using diffusion-weighted (DW) MRI. In this population, there has been a focus on examining diffusion in the white matter, but the greymatter is also critically important for neurological health. We acquired multi-shell high-resolution diffusion data on 12 infants born at