Cellular immune responses to acute stress in female caregivers of dementia patients and matched controls.
Cellular immune responses to acute stress in female caregivers of dementia patients and matched controls.
复制标题
痴呆症患者的女性护理人员和匹配对照者对急性应激的细胞免疫反应。
DOI：
10.1037//0278-6133.17.2.182
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Glaser,R
中科院分区：
文献类型：
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作者：
Cacioppo,JT;Poehlmann,KM;Kiecolt-Glaser,JK;Malarkey,WB;Burleson,MH;Berntson,GG;Glaser,R
这项研究调查了护理压力是否会改变细胞对急性心理压力源的免疫反应。照顾患有进行性痴呆（高慢性压力）配偶的 27 名女性和 37 名年龄和家庭收入相匹配的对照组进行了 12 分钟的实验室压力测试。通过在暴露于实验室压力源之前（低急性应激）、之后立即（高急性应激）和30分钟后（从应激中恢复）采取的功能和定量测量来评估细胞免疫功能。实验室挑战与增殖反应减弱但自然杀伤（NK）细胞毒性升高有关；然而，随后的分析表明，这种细胞毒性的升高很大程度上归因于外周血中 NK 细胞数量的增加。结果表明，虽然看护的压力会削弱细胞免疫功能，但看护似乎对细胞免疫对短暂心理挑战的反应或恢复影响不大。（PsycInfo 数据库记录 (c) 2021 APA，保留所有权利）
This study investigated whether the stress of caregiving alters cellular immune responses to acute psychological stressors. Twenty-seven women caring for a spouse with a progressive dementia (high chronic stress) and 37 controls matched for age and family income performed a 12-min laboratory stressor. Cellular immune function was assessed by both functional and quantitative measures taken before (low acute stress), immediately after (high acute stress), and 30 min after (recovery from stress) exposure to the laboratory stressors. The laboratory challenges were associated with diminished proliferative responses but elevated natural killer (NK) cell cytotoxicity; however, subsequent analyses suggested that this elevated cytotoxicity was largely attributable to an increase in the number of NK cells in peripheral blood. The results suggest that although the stress of caregiving diminishes cellular immune function, caregiving appears to have little effect on cellular immune responses to or recovery from brief psychological challenges.(PsycInfo Database Record (c) 2021 APA, all rights reserved)