Age alters the observed response of imipramine binding sites to chronic antidepressant treatment in female rats.
Age alters the observed response of imipramine binding sites to chronic antidepressant treatment in female rats.
复制标题
年龄改变了雌性大鼠中观察到的丙咪嗪结合位点对长期抗抑郁治疗的反应。
DOI：
10.1016/0014-2999(84)90726-x
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发表时间：
1984
影响因子：
5
通讯作者：
Roy,EJ
中科院分区：
文献类型：
--
作者：
Wilson,MA;Roy,EJ
年龄改变雌性大鼠下丘脑丙咪嗪结合位点。老年女性丙咪嗪结合水平升高，亲和力降低。下丘脑丙咪嗪结合位点对慢性抗抑郁药物治疗的反应取决于治疗动物的年龄。在幼年雌性大鼠中，抗抑郁药治疗后丙咪嗪结合位点减少，与先前的报道一致。然而，在年轻女性慢性丙咪嗪治疗中，丙咪嗪结合水平没有变化，结合亲和力略有下降。在中年雌性大鼠中，同样的处理导致丙咪嗪结合位点水平明显增加，同时亲和力降低。在老年雌性大鼠中，丙咪嗪结合位点的亲和力降低，以及伴随的丙咪嗪结合水平的变化，是丙咪嗪代谢物在抗抑郁药物治疗后残留在组织中，并干扰结合试验的结果，尽管对膜制备进行了大量清洗。因此，观察到的丙咪嗪结合位点对慢性丙咪嗪治疗的反应随年龄的变化可能是由于雌性大鼠丙咪嗪代谢的年龄相关改变。
Age alters hypothalamic imipramine binding sites in female rats. Older females have increased levels of imipramine binding with decreased affinity. The response of hypothalamic imipramine binding sites to chronic antidepressant treatment varies depending on the age of the animals treated. In juvenile female rats imipramine binding sites decrease after antidepressant treatment, consistent with previous reports. However, in young females chronic imipramine treatment produces no change in levels of imipramine binding with a slight decrease in binding affinity. In middle-aged female rats, the same treatment causes an apparent increase in levels of imipramine binding sites along with a decrease in affinity. These decreases in the affinity of imipramine binding sites in older female rats, and the concomitant changes in the levels of imipramine binding are the result of imipramine metabolites remaining in the tissue after antidepressant treatment and interfering with the binding assay, despite extensive washing of the membrane preparation. Thus, the observed changes in the response of imipramine binding sites to chronic imipramine treatment with age are probably due to age-related alterations in the metabolism of imipramine in female rats.