The draft genome of Ciona intestinalis:: Insights into chordate and vertebrate origins
The draft genome of Ciona intestinalis:: Insights into chordate and vertebrate origins
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DOI：
10.1126/science.1080049
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发表时间：
2002-12-13
期刊：
影响因子：
56.9
通讯作者：
Rokhsar, DS
中科院分区：
文献类型：
--
作者：
Dehal, P;Satou, Y;Rokhsar, DS
第一批脊索动物出现在化石记录中，时间是近 5.5 亿年前的寒武纪大爆发。现代海鞘蝌蚪代表了这些祖先脊索动物的合理近似。为了阐明脊索动物和脊椎动物的起源，我们绘制了研究最多的海鞘（海鞘）基因组蛋白质编码部分的草图。海鞘基因组包含大约 16,000 个蛋白质编码基因，与其他无脊椎动物中的数量相似，但只有脊椎动物中的一半。脊椎动物基因家族通常以简化形式存在于海鞘中，这表明海鞘含有参与细胞信号传导和发育的基本祖先基因。海鞘基因组还获得了许多谱系特异性创新，包括一组与细菌和真菌相关的参与纤维素代谢的基因。
The first chordates appear in the fossil record at the time of the Cambrian explosion, nearly 550 million years ago. The modern ascidian tadpole represents a plausible approximation to these ancestral chordates. To illuminate the origins of chordate and vertebrates, we generated a draft of the protein-coding portion of the genome of the most studied ascidian, Ciona intestinalis. The Ciona genome contains similar to16,000 protein-coding genes, similar to the number in other invertebrates, but only half that found in vertebrates. Vertebrate gene families are typically found in simplified form in Ciona, suggesting that ascidians contain the basic ancestral complement of genes involved in cell signaling and development. The ascidian genome has also acquired a number of lineage-specific innovations, including a group of genes engaged in cellulose metabolism that are related to those in bacteria and fungi.