Donor MEGX test fails to predict graft function after orthotopic liver transplant
Donor MEGX test fails to predict graft function after orthotopic liver transplant
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DOI：
10.1016/s0041-1345(96)00126-1
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发表时间：
1997-02-01
影响因子：
0.9
通讯作者：
Neuhaus, P
中科院分区：
文献类型：
--
作者：
Dette, K;Knoop, M;Neuhaus, P
MATERIALS AND METHODSFrom May 1991 to December 1995 we performed MEGX tests in 243 liver donors. Eleven grafts were not transplanted because of macroscopic gross steatosis (n= 10) and fibrosis in combination with insufficient perfusion (n= 1). Twelve grafts had to be excluded from analysis because of elevated MEGX levels (> 20 ng/mL) before application of lidocaine bolus. The MEGX test was performed before organ retrieval as bolus injection of 1 mgkg, and blood samples were collected before and 15 minutes after injection as previously described by Oellerich et al.’All organs were harvested by surgeons from our institution, and preservation was carried out as arterial pressure perfusion with 1000 mL and portal perfusion with 2000 mL University of Wisconsin (VW) solution. Selection of organs for transplantation was independent from MEGX test results. Initial poor function (IPF) was defined as rise of SGOT above 1000 U/L within the first 72 hours and low initial bile flow (< 50 mL/first 24 h). Primary nonfunction (PNF) was defined as severe graft dysfunction requiring retransplantation within 7 days after OLT.For analyzing the early postoperative outcome we devided the grafts into three groups according to the MEGX test results in the donor: less than 50, 50 to 90, and more than 90 ng/mL. Statistical analysis was performed using Kruskal-Wallis test and the chisquare test when appropriate.
