20 year experience of postoperative radiotherapy in IB-IIA cervical cancer patients with intermediate risk factors: Impact of treatment period and concurrent chemotherapy
20 year experience of postoperative radiotherapy in IB-IIA cervical cancer patients with intermediate risk factors: Impact of treatment period and concurrent chemotherapy
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DOI：
10.1016/j.ygyno.2011.09.033
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发表时间：
2012-01-01
影响因子：
4.7
通讯作者：
Ha, Sung W.
中科院分区：
文献类型：
--
作者：
Song, Sanghyuk;Song, Changhoon;Ha, Sung W.
目标。比较辅助放疗（RT）与同步放化疗（CCRT）治疗有中间危险因素的宫颈癌患者的长期临床疗效。1990 - 2010年间，110例伴有2种及以上中间危险因素（深部间质浸润、淋巴血管间隙浸润、肿瘤较大）的宫颈癌患者在根治性手术后行辅助RT （n = 56）或CCRT （n = 54）。由于从2000年开始进行CCRT，根据治疗时间和化疗的添加情况将患者分为3组，RT 1990-1999 (n = 39), RT 2000-2010 （n = 17）和CCRT 2000-2010 （n = 54）。大多数同时化疗方案是卡铂和紫杉醇（n = 48）。RT 1990-1999、RT 2000-2010和CCRT 2000-2010的5年无复发生存率（RFS）分别为83.5%、85.6%和93.8%。CCRT 2000-2010年盆腔复发率（p = 0.012）和远处转移率（p = 0.027）显著降低。RT 1990-1999和RT 2000-2010的总生存期和RFS无显著差异。急性3级和4级血液学毒性在ccRT 2000-2010中更为常见(p
Objective. To compare the long-term clinical outcomes of adjuvant radiotherapy (RT) versus concurrent chemoradiotherapy (CCRT) in cervical cancer patients with intermediate risk factors.Methods. Between 1990 and 2010, 110 cervical cancer patients with 2 or more intermediate risk factors (deep stromal invasion, lymphovascular space invasion, and large tumor size) underwent adjuvant RT (n = 56) or CCRT (n = 54) following radical surgery. Because CCRT had been performed since 2000, patients were divided into 3 groups regarding treatment period and the addition of chemotherapy, RT 1990-1999 (n = 39), RT 2000-2010 (n = 17) and CCRT 2000-2010 (n = 54). Majority of concurrent chemotherapeutic regimens were carboplatin and paclitaxel (n = 48).Results. Five-year relapse-free survival (RFS) rates for RT 1990-1999, RT 2000-2010 and CCRT 2000-2010 were 83.5%, 85.6% and 93.8%, respectively. CCRT 2000-2010 had a significant decrease in pelvic recurrence (p = 0.012) and distant metastasis (p = 0.027). There were no significant differences in overall survival and RFS between RT 1990-1999 and RT 2000-2010. Acute grade 3 and 4 hematologic toxicities were more frequently observed in ccRT 2000-2010 (p