Probiotic Escherichia coli Nissle 1917 versus placebo for treating diarrhea of greater than 4 days duration in infants and toddlers
Probiotic Escherichia coli Nissle 1917 versus placebo for treating diarrhea of greater than 4 days duration in infants and toddlers
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DOI：
10.1097/inf.0b013e318169034c
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发表时间：
2008-06-01
影响因子：
3.6
通讯作者：
Schulze, Juergen
中科院分区：
文献类型：
--
作者：
Henker, Jobst;Laass, Martin W.;Schulze, Juergen
背景：服用益生菌可以预防或治疗某些形式的腹泻。采用双盲试验方法，对151例1-47个月非特异性腹泻患儿随机分为两组，每组75例，对照组76例，观察益生菌Escherichia coli Nissle 1917（EcN）治疗婴幼儿腹泻的疗效。腹泻必须符合以下定义：腹泻发作24小时内> 3次水样便或稀便，无血便，持续时间> 4天，但幼儿为4天。
Background: Administering probiotics can prevent or cure some forms of diarrhea. The efficacy of probiotic Escherichia coli Nissle 1917 (EcN) in infants and toddlers with diarrhea > 4 days was tested by a double-blind trial.Methods: One hundred fifty-one children aged 1-47 months with nonspecific diarrhea were randomized to receive either EcN suspension (N = 75) or placebo (N = 76). Diarrhea had to meet the following definition: > 3 watery or loose nonbloody stools in 24 hours of a diarrheal episode persisting for > 4 consecutive days but 4 days in young children.