Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999-2000
Prevalence of impaired fasting glucose and its relationship with cardiovascular disease risk factors in US adolescents, 1999-2000
复制标题
DOI：
10.1542/peds.2004-2001
复制
发表时间：
2005-11-01
期刊：
影响因子：
8
通讯作者：
Imperatore, G
中科院分区：
文献类型：
--
作者：
Williams, DE;Cadwell, BL;Imperatore, G
Objective.几项研究报告了年轻人2型糖尿病发病率的增加。患有糖尿病前期状态（如空腹血糖受损（IFG））的人患糖尿病和心血管疾病（CVD）的风险增加。本研究的目的是检查IFG的患病率及其与超重和心血管疾病危险因素的关系，在一个全国代表性的样本，美国青少年谁是12至19岁。我们使用的数据来自1999 - 2000年国家健康和营养调查（NHANES）。禁食8小时或以上的青少年被纳入研究（n = 915）。IFG定义为空腹血糖100 - 125 mg/dL。当参与者的年龄和性别特异性BMI>=第95百分位数时，他们被归类为超重，当他们的BMI>=第85和<第95百分位数时，他们被归类为超重风险。1999 - 2000年，美国青少年IFG的患病率为7.0%，男孩高于女孩（10.0%比4.0%）。IFG的患病率在超重青少年中较高（17.8%），但在体重正常和有超重风险的青少年中相似（5.4% vs 2.8%）。IFG的患病率在不同种族/民族之间存在显著差异（墨西哥裔美国人、非西班牙裔黑人个体和非西班牙裔白色个体分别为13.0%、4.2%和7%）。与空腹血糖浓度正常的青少年相比，IFG青少年的平均血红蛋白A1 c、空腹胰岛素、总胆固醇和低密度脂蛋白胆固醇、甘油三酯、收缩压显著升高，高密度脂蛋白胆固醇显著降低。这些数据代表了2700万美国青少年，揭示了青少年中IFG的患病率非常高（10个男孩中有1个，25个女孩中有1个）;每6个超重青少年中就有1个患有IFG。IFG青少年具有胰岛素抵抗和心血管危险因素加重的特点。在这一年龄组，预防的证据仍在不断涌现。
Objective. Several studies have reported increases in the occurrence of type 2 diabetes in youths. People with prediabetic states such as impaired fasting glucose (IFG) are at increased risk for developing diabetes and cardiovascular disease (CVD). The objective of this study was to examine the prevalence of IFG and its relationship with overweight and CVD risk factors in a nationally representative sample of US adolescents who were aged 12 to 19 years.Methods. We used data from the 1999 - 2000 National Health and Nutrition Examination Survey ( NHANES). Adolescents who had fasted for 8 hours or more were included in the study (n = 915). IFG was defined as a fasting glucose of 100 to 125 mg/dL. Participants were classified as overweight when their age- and gender-specific BMI was >= 95th percentile and as at-risk for overweight when their BMI was >= 85th and < 95th percentile.Results. In 1999 - 2000, the prevalence of IFG in US adolescents was 7.0% and was higher in boys than in girls (10.0% vs 4.0%). Prevalence of IFG was higher in overweight adolescents (17.8%) but was similar in those with normal weight and those who were at risk for overweight (5.4% vs 2.8%). The prevalence of IFG was significantly different across racial/ethnic groups (13.0%, 4.2%, and 7% in Mexican Americans, non-Hispanic black individuals, and non-Hispanic white individuals, respectively). Adolescents with IFG had significantly higher mean hemoglobin A1c, fasting insulin, total and low-density lipoprotein cholesterol, triglycerides, and systolic blood pressure and lower high-density lipoprotein cholesterol than those with normal fasting glucose concentrations.Conclusions. These data, representing 27 million US adolescents, reveal a very high prevalence of IFG ( 1 in 10 boys and 1 in 25 girls) among adolescents; the condition affects 1 in every 6 overweight adolescents. Adolescents with IFG have features of insulin resistance and worsened CVD risk factors. Evidence for prevention is still forthcoming in this age group.