The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression
The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression
复制标题
DOI：
10.1093/ndt/gfq818
复制
发表时间：
2011-03-01
影响因子：
6.1
通讯作者：
Evenepoel, Pieter
中科院分区：
文献类型：
--
作者：
Meijers, Bjorn K. I.;Evenepoel, Pieter
“尿素的特殊位置似乎是从尿素不能合成形成的时候开始的，人们认为尿素只存在于生物中。既然尿素是人工形成的，它的许多奥秘就被剥夺了。(阿尔·库什尼，《尿液的分泌》，1917年)自从库什尼近一个世纪前出版经典专著以来，对尿毒症毒性的基本见解几乎没有什么进展[1]。有机代谢物仍然被认为是尿毒症的主要诱因(尽管尿素可能不是罪魁祸首)，但缺乏明确证明任何一种尿毒症成分的毒性的证据[2]。
‘The special position assigned to urea appears to date from the time at which urea could not be formed synthetically and was believed to arise only in living matter. Now that urea is formed artificially, it has been robbed of much of its mystery.’(AR Cushny, The secretion of urine, 1917)The fundamental insights into uraemic toxicity have evolved little since publication of the classical monograph by Cushny nearly a century ago [1]. Organic metabolites are still thought to substantially contribute to uremia (albeit urea might not be the culprit), yet evidence unequivocally demonstrating toxicity of any single uraemic constituent is lacking [2].