Dietary supplement use among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study.
Dietary supplement use among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study.
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儿童癌症成年幸存者中膳食补充剂的使用：来自圣裘德终身队列研究的报告。
作者：
Zhang,FangFang;Hudson,MelissaM;Chen,Fan;Li,Zhongyu;Huang,I-Chan;Bhakta,Nickhill;Ness,KirstenK;Brinkman,TaraM;Klosky,James;Ojha,RohitP;Lanctot,JenniferQ;Robison,LeslieL;Krull,KevinR
儿童癌症的成年幸存者对营养指南的依从性很差，饮食中维生素D和E、钾、纤维、镁和钙的摄入量不足。维生素和矿物质补充剂的使用对该人群总营养素摄入量的贡献尚不清楚。方法我们调查了参加圣裘德终身队列研究的2570名成年癌症幸存者的营养素摄入量和患病率，以及膳食补充剂使用与治疗暴露、症状负担和生活质量的关系。结果近40%的成年癌症幸存者报告经常使用膳食补充剂。尽管服用膳食补充剂的癌症幸存者不太可能有几种营养素的摄入量不足，但与不服用膳食补充剂的幸存者相比，他们也更有可能摄入过量的叶酸(15.4%比1.3%)、维生素A(12.2%比0.2%)、铁(27.8%比1.2%)、锌(18.6%比1%)和钙(5.1%比0.9%)。治疗暴露、症状负担和身体功能与补充剂的使用无关，而儿童癌症幸存者的情绪幸福感和活力与补充剂的使用呈正相关。结论补充剂的使用与特定营养素的摄入不足和过量有关，但对儿童癌症幸存者的生活质量有积极影响。
BackgroundAdult survivors of childhood cancer have poor adherence to nutrition guidelines and inadequate intake of dietary vitamins D and E, potassium, fiber, magnesium, and calcium. The contribution of vitamin and mineral supplement use to total nutrient intake in this population is unclear.MethodsWe examined the prevalence and dose of nutrient intake among 2570 adult survivors of childhood cancer participating in the St. Jude Lifetime Cohort Study, and the association of dietary supplement use with treatment exposures, symptom burden, and quality of life.ResultsNearly 40% of the adult survivors of cancer survivors reported regular use of dietary supplements. Although cancer survivors who used dietary supplements were less likely to have inadequate intake of several nutrients, they were also more likely to have excessive intake (total nutrient intake ≥ tolerable upper intake levels) of folate (15.4% vs. 1.3%), vitamin A (12.2% vs. 0.2%), iron (27.8% vs. 1.2%), zinc (18.6% vs. 1%), and calcium (5.1% vs. 0.9%) compared with survivors who did not use dietary supplements (allp< 0.05). Treatment exposures, symptom burden, and physical functioning were not associated with supplement use, whereas emotional well‐being and vitality were positively associated with supplement use among childhood cancer survivors.ConclusionsSupplement use is associated with both inadequate and excessive intake of specific nutrients, but positively impacts aspects of quality of life among childhood cancer survivors.