Is bacterial persistence a social trait?
Is bacterial persistence a social trait?
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DOI：
10.1371/journal.pone.0000752
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发表时间：
2007-08-15
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
近年来，细菌对抗生素产生耐药性的能力得到了大量报道。不太为人所知的是，在细菌群体中，有一些细胞由于非遗传表型转换到缓慢生长状态而具有耐药性。尽管这种“持久”细胞正受到越来越多的关注，但其中涉及的进化力量却相对被忽视了。坚持对细胞有直接的好处，因为它允许在灾难中生存--一种更好的对冲形式。然而，持之以恒也可以给其他人带来间接的好处，因为增长速度的降低可以减少对有限资源的竞争。这增加了坚持性是一种社会特征的可能性，这可能会受到亲属选择的影响。我们开发了一个理论模型来研究坚持的社会后果。我们预测，当：(A)细胞相关(例如，单个克隆谱系)；以及(B)资源稀缺时，持久性的选择会增加。我们的模型使我们能够预测持久力水平应该如何随着时间、跨人群、对干预策略和竞争水平的反应而变化。更广泛地说，我们的结果澄清了坚持性和其他押注对冲或社交行为之间的联系。
The ability of bacteria to evolve resistance to antibiotics has been much reported in recent years. It is less well-known that within populations of bacteria there are cells which are resistant due to a non-inherited phenotypic switch to a slow-growing state. Although such ‘persister’ cells are receiving increasing attention, the evolutionary forces involved have been relatively ignored. Persistence has a direct benefit to cells because it allows survival during catastrophes–a form of bet-hedging. However, persistence can also provide an indirect benefit to other individuals, because the reduced growth rate can reduce competition for limiting resources. This raises the possibility that persistence is a social trait, which can be influenced by kin selection. We develop a theoretical model to investigate the social consequences of persistence. We predict that selection for persistence is increased when: (a) cells are related (e.g. a single, clonal lineage); and (b) resources are scarce. Our model allows us to predict how the level of persistence should vary with time, across populations, in response to intervention strategies and the level of competition. More generally, our results clarify the links between persistence and other bet-hedging or social behaviours.