Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms.

Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms.
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DOI:
10.3390/genes13091618
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发表时间:
2022-09-09
期刊:
影响因子:
3.5
通讯作者:
Sawada, Hisashi
Sawada, Hisashi
中科院分区:
生物学3区
文献类型:
--
作者:
Ito, Sohei;Lu, Hong S.;Daugherty, Alan;Sawada, Hisashi

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平滑肌细胞(SMCs)是主动脉壁的主要细胞类型,在胸主动脉瘤(TAAs)的病理生理中起着关键作用。taa以特定区域的方式发生,近端区域是常见的位置。在这一区域,胚性间充质干细胞来源于心脏神经嵴或第二心野。在复杂的TAAs机制中,这些起源不同的细胞分布在特定的位置,表现出不同的生物学行为。本综述的目的是加强对近段胸主动脉SMCs的胚胎异质性及其在TAAs中的功能的了解。
Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.
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