Bradykinin elevates tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in PC12 cells.
Bradykinin elevates tyrosine hydroxylase and dopamine beta-hydroxylase mRNA levels in PC12 cells.
复制标题
缓激肽可提高 PC12 细胞中酪氨酸羟化酶和多巴胺 β-羟化酶 mRNA 水平。
DOI：
10.1016/0006-8993(93)91477-a
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发表时间：
1993
期刊：
影响因子：
2.9
通讯作者：
Sabban,EL
中科院分区：
文献类型：
--
作者：
Gebreyesus,K;Kilbourne,EJ;Sabban,EL
已知缓激肽能迅速升高细胞内钙，导致神经递质分泌和酪氨酸羟化酶（TH）的短期激活。在本研究中，我们检测了缓激肽对两种儿茶酚胺生物合成酶mRNA水平的影响。1 μM缓激肽作用PC12细胞3 h后，TH和多巴胺β-羟化酶（DBH） mRNA水平均显著升高。
Bradykinin is known to rapidly elevate intracellular calcium leading to secretion of neurotransmitters and short term activation of tyrosine hydroxylase (TH). In this study we examined the effect of bradykinin on mRNA levels of two catecholamine biosynthetic enzymes. Treatment of PC12 cells with 1 μM bradykinin for 3 h markedly elevated both TH and dopamine β-hydroxylase (DBH) mRNA levels.