Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease
Evidence from functional neuroimaging of a compensatory prefrontal network in Alzheimer's disease
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DOI：
10.1523/jneurosci.23-03-00986.2003
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发表时间：
2003-02-01
影响因子：
5.3
通讯作者：
Black, SE
中科院分区：
文献类型：
--
作者：
Grady, CL;McIntosh, AR;Black, SE
先前的实验已经发现，在认知任务中，与健康的年龄匹配的对照组相比，阿尔茨海默病（AD）患者的前额叶区域活动增加。这被解释为认知资源的补偿性重新分配，但缺乏直接证据表明对绩效的促进作用。为了解决这个问题，我们测量了轻度痴呆AD患者和健康老年人对照组在语义和情景记忆任务中的神经活动。控制招募了左半球的区域网络，包括前额叶和颞叶皮层在语义和情节任务。患者参与了一个独特的网络，涉及双侧背外侧前额叶和后皮质。重要的是，这个区域网络中的活动与患者在语义和情景任务上的更好表现相关。这提供了迄今为止最直接的证据，即AD患者可以使用前额叶皮层中的额外神经资源，可能是那些介导执行功能的神经资源，以补偿归因于疾病退行性过程的损失。
Previous experiments have found that individuals with Alzheimer's disease (AD) show increased activity in prefrontal regions compared with healthy age-matched controls during cognitive tasks. This has been interpreted as compensatory reallocation of cognitive resources, but direct evidence for a facilitating effect on performance has been lacking. To address this we measured neural activity during semantic and episodic memory tasks in mildly demented AD patients and healthy elderly controls. Controls recruited a left hemisphere network of regions, including prefrontal and temporal cortices in both the semantic and episodic tasks. Patients engaged a unique network involving bilateral dorsolateral prefrontal and posterior cortices. Critically, activity in this network of regions was correlated with better performance on both the semantic and episodic tasks in the patients. This provides the most direct evidence to date that AD patients can use additional neural resources in prefrontal cortex, presumably those mediating executive functions, to compensate for losses attributable to the degenerative process of the disease.