Does magnesium sulfate alter the maternal cardiovascular response to vasopressor agents in gravid ewes?
Does magnesium sulfate alter the maternal cardiovascular response to vasopressor agents in gravid ewes?
复制标题
硫酸镁是否会改变妊娠母羊母体心血管对血管加压药的反应？
DOI：
10.1097/00000542-199112000-00013
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发表时间：
1991
期刊：
影响因子：
8.8
通讯作者：
Chatterjee,P
中科院分区：
文献类型：
--
作者：
Sipes,SL;Chestnut,DH;VincentJr,RD;Weiner,CP;Thompson,CS;Chatterjee,P
硫酸镁（MgSO 4）减弱母体对妊娠母羊出血的代偿反应，可能是通过降低对内源性血管加压素的反应。本研究的目的是确定硫酸镁是否改变妊娠母羊的心血管反应血管加压剂。16只妊娠母羊进行了一系列实验，包括两种外源性和两种内源性血管加压药的给药，每种都有和没有并发的MgSO 4输注。构建苯肾上腺素（α 1-肾上腺素能激动剂）、ST-91（α 2-肾上腺素能激动剂）、血管紧张素II和精氨酸加压素（AVP）的剂量-反应曲线。MgSO 4显着衰减母体平均动脉压和全身血管阻力的增加和ST-91输注期间心输出量的减少，但在苯肾上腺素，血管紧张素II，或AVP输注。MgSO 4显著减弱了苯肾上腺素、ST-91和血管紧张素II输注过程中子宫血管阻力的增加，以及苯肾上腺素和血管紧张素II输注过程中子宫血流量的减少。硫酸镁似乎还可以减弱ST-91输注期间子宫血流量的减少（P= 0.067）。本研究表明，硫酸镁拮抗α 1-肾上腺素能激动剂，α 2-肾上腺素能激动剂，血管紧张素II对子宫血管的影响，从而提供了一定程度的保护胎儿在母体压力的情况下。
Magnesium sulfate (MgSO4) attenuates the maternal compensatory response to hemorrhage in gravid ewes, perhaps by decreasing the response to endogenous vasopressors. The purpose of this study was to determine whether MgSO4 alters the cardiovascular response of gravid ewes to vasopressor agents. Sixteen gravid ewes underwent a series of experiments consisting of administration of two exogenous and two endogenous vasopressors, each with and without a concurrent MgSO4 infusion. Dose-response curves were constructed for phenylephrine (an alpha 1-adrenergic agonist), ST-91 (an alpha 2-adrenergic agonist), angiotensin II, and arginine vasopressin (AVP). MgSO4 significantly attenuated the increase in maternal mean arterial pressure and systemic vascular resistance and the decrease in cardiac output during ST-91 infusion but not during phenylephrine, angiotensin II, or AVP infusions. MgSO4 significantly attenuated the increase in uterine vascular resistance during phenylephrine, ST-91, and angiotensin II infusions and the decrease in uterine blood flow during phenylephrine and angiotensin II infusions. MgSO4 also appeared to attenuate the decrease in uterine blood flow during ST-91 infusion (P= 0.067). The present study suggests that MgSO4 antagonizes the effects of alpha 1-adrenergic agonists, alpha 2-adrenergic agonists, and angiotensin II on the uterine vasculature, thus providing a level of protection for the fetus in situations of maternal stress.