Cancer Stem Cells and Self-renewal
Cancer Stem Cells and Self-renewal
复制标题
DOI：
10.1158/1078-0432.ccr-09-2824
复制
发表时间：
2010-06-15
影响因子：
11.5
通讯作者：
Jamieson, Catriona H. M.
中科院分区：
文献类型：
--
作者：
O'Brien, Catherine Adell;Kreso, Antonija;Jamieson, Catriona H. M.
自从Dick和他的同事发表了一篇具有开创性的报告，表明白血病细胞之间存在着层次结构以来，癌症干细胞（CSC）或癌症启动性癌症（C-IC）模型在过去几年中引起了相当大的关注。近年来，在多种实体肿瘤中发现了类似的分层组织，其顶端存在CSC。人类CSCs的定义是通过它们的能力：(1)产生组织学上与母肿瘤相似的异种移植物，(2)在异种移植物试验中连续移植，从而显示出自我更新（再生）的能力，(3)产生具有一定增殖能力的子细胞，但由于缺乏内在的再生潜力，无法启动或维持癌症。CSC表型和功能的新兴复杂性有时令人生畏，并导致该领域的一些混乱。然而，CSC模型的核心是识别和表征具有最大再生肿瘤各方面能力的癌细胞。越来越清楚的是，癌细胞的进化是它们劫持正常自我更新途径的能力的结果，这一过程可以驱动恶性转化。在癌症和CSC维持的背景下研究自我更新将有助于更好地理解驱动肿瘤生长的机制。本文将讨论CSC领域的一些主要争议，并强调首先关注CSC的定义特征的重要性：失调的自我更新能力。临床癌症研究；16 (12);3113 - 20。AACR (C) 2010。
The cancer stem cell (CSC) or cancer-initiating cancer (C-IC) model has garnered considerable attention over the past several years since Dick and colleagues published a seminal report showing that a hierarchy exists among leukemic cells. In more recent years, a similar hierarchical organization, at the apex of which exists the CSC, has been identified in a variety of solid tumors. Human CSCs are defined by their ability to: (i) generate a xenograft that histologically resembles the parent tumor from which it was derived, (ii) be serially transplanted in a xenograft assay thereby showing the ability to self-renew (regenerate), and (iii) generate daughter cells that possess some proliferative capacity but are unable to initiate or maintain the cancer because they lack intrinsic regenerative potential. The emerging complexity of the CSC phenotype and function is at times daunting and has led to some confusion in the field. However, at its core, the CSC model is about identifying and characterizing the cancer cells that possess the greatest capacity to regenerate all aspects of the tumor. It is becoming clear that cancer cells evolve as a result of their ability to hijack normal self-renewal pathways, a process that can drive malignant transformation. Studying self-renewal in the context of cancer and CSC maintenance will lead to a better understanding of the mechanisms driving tumor growth. This review will address some of the main controversies in the CSC field and emphasize the importance of focusing first and foremost on the defining feature of CSCs: dysregulated self-renewal capacity. Clin Cancer Res; 16(12); 3113-20. (C)2010 AACR.