Are Prostaglandins Involved in Experimental Ischemic Edema in Gerbils?
Are Prostaglandins Involved in Experimental Ischemic Edema in Gerbils?
复制标题
前列腺素是否与沙鼠实验性缺血性水肿有关？
作者：
F. Iannotti;A. Crockard;G. Ladds;L. Symon
本研究选用65只雄性沙鼠，分为3组，采用氢洗净技术将局灶性脑比重与相应的局灶性脑血流量进行比较。行单侧或双侧颈动脉颅外结扎术，1小时后处死足趾动物。当局灶血流量小于20 ml/100 g/mln时，水肿发生并随着缺血的进展而加重，在5-7 ml/100 g/mln时达到最大值。在零流量情况下，无水肿。另外两组用吲哚美辛或地塞米松预处理，在20-12 ml/100 g/min流速下，并不能防止水肿的形成，但在低流速（5-7 ml/100 g/min）下，可显著减轻水肿。药物对缺血区血流减少无影响。我们得出结论，前列腺素，由膜破坏释放，参与缺血性水肿的发展。
Sixty-five male gerbils, divided into 3 groups, were used in this study, in which focal brain specific gravity, taken as a measure of edema, was compared to the corresponding focal cerebral blood flow using the hydrogen washout technique. Extracranlal unilateral or bilateral carotid ligation was performed and one hour later toe animal was sacrificed. When focal blood flow was less than 20 ml/100 g/mln, edema developed and increased with progressive ischemia, reaching maximal values at 5-7 ml/100 g/mln. In the zero flow situation there was no edema. Pretreatment of the other 2 groups with indomethacin or dexamethasone, did not prevent edema formation at flows of 20-12 ml/100 g/min, but considerably reduced the edema previously noted at low flows (5-7 ml/100 g/min). The drugs did not affect the decreased flow in the iscbemic area. We conclude that prostaglandins, released by membrane disruption, are involved in the development of ischemic edema.