New Insights Into Dietary Toxin Metabolism: Diversity in the Ability of the Natricine Snake Rhabdophis tigrinus to Convert Toad-Derived Bufadienolides
New Insights Into Dietary Toxin Metabolism: Diversity in the Ability of the Natricine Snake Rhabdophis tigrinus to Convert Toad-Derived Bufadienolides
复制标题
对膳食毒素代谢的新见解：Natricine 蛇 Rhabdophis tigrinus 转化蟾蜍衍生的蟾蜍二烯内酯的能力的多样性
DOI：
10.1007/s10886-021-01287-6
复制
发表时间：
2021
影响因子：
2.3
通讯作者：
Mori Naoki
中科院分区：
文献类型：
--
作者：
Inoue Takato;Nakata Ryu;Savitzky Alan H.;Yoshinaga Naoko;Mori Akira;Mori Naoki
日本毒蛇Rhabtopis tigrinus将强心类固醇Bufadienoldes(BDS)作为防御性毒素从摄取的蟾蜍颈腺中分离出来。先前的一项研究表明。圈养虎豆素在隔离饮食中的BDS时会将它们转化为BDS。然而，目前尚不清楚膳食中的BDS是否实际上是在自然条件下转化和修饰的产品积累的。摄取的蟾蜍的BD特征在多大程度上反映在蛇的BD特征中也是未知的。我们从日本各地收集了123条蛇，用液相色谱/质谱仪分析了它们的BD谱，从R中鉴定了15种BD。老虎的核磁共振分析。我们还使用层次聚类分析(HCA)比较了他们的BD资料。HCA展示了与其收集地点有关的两个主要集群：日本主要岛屿的东部和西部地区。这些结果，再加上之前对日本蟾蜍BDS的发现，表明1)虎纹伊蚊在自然条件下将蟾蜍来源的BDS转化为其他化合物；2)饮食中BDS的转化既有普遍性的，也有地区性的。3)青蛙BD剖面的地理变异部分反映在蛇BD剖面的变异上。
The Japanese natricine snakeRhabdophis tigrinussequesters cardiotonic steroids, bufadienolides (BDs), from ingested toads in the nuchal glands as defensive toxins. A previous study showed thatR. tigrinusin captivity converts dietary BDs when it sequesters them. However, it is unknown whether the dietary BDs are actually converted and the modified products accumulated under natural conditions. It is also unknown to what extent the BD profile of ingested toads is reflected in that of the snake. We collected 123 snakes from throughout Japan, analyzed their BD profiles by liquid chromatography/mass spectrometry, and identified 15 BDs fromR. tigrinusby nuclear magnetic resonance analyses. We also compared their BD profiles using hierarchical cluster analysis (HCA). HCA exhibited two main clusters associated with their collection locations: eastern and western regions of the Japanese main islands. These results, coupled with previous findings on the BDs of Japanese toads, suggest that 1)R. tigrinusconverts toad-derived BDs into other compounds under natural conditions; 2) there are both universal and regionally-specific conversions of dietary BDs byR. tigrinus; and 3) geographic variation in toad BD profiles is partially reflected in the variation of snake BD profiles.
登录
查看更多内容
影响因子：
--
作者：
M. Speed;G. Ruxton;J. Mappes;T. Sherratt
通讯作者：
T. Sherratt
影响因子：
0.7
作者：
Koji Tanaka;A. Mori
通讯作者：
A. Mori
影响因子：
2.6
作者：
Takeuchi H;Savitzky AH;Ding L;de Silva A;Das I;Nguyen TT;Tsai TS;Jono T;Zhu GX;Mahaulpatha D;Tang Y;Mori A
通讯作者：
Mori A
甾体16，17-稠合不饱和δ-内酯的合成
影响因子：
3.6
作者：
B. Green;R. Crane;I. S. Khaidem;R. Leighton;S. S. Newaz;T. E. Smyser
通讯作者：
T. E. Smyser
Rhabdophis conspicillatus（红腹龙骨鱼）。
影响因子：
--
作者：
Fujishima;K.;K. Nishikawa;S. Hara;and M. Y. Hossman
通讯作者：
and M. Y. Hossman